东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

脉冲式及伪连续式动脉自旋标记技术静息态脑灌注对比研究

ISSN号：1000-6737
期刊名称：《生物物理学报》
时间：0
分类：R445.2[医药卫生—影像医学与核医学;医药卫生—诊断学;医药卫生—临床医学] R318[医药卫生—生物医学工程;医药卫生—基础医学]
作者机构：[1]南京航空航天大学自动化学院生物医学工程系,南京210016, [2]南京军区南京总医院影像科,南京210002, [3]南京航空航天大学民航学院民航工程系,南京210016
相关基金：国家自然科学基金项目（61171059,30470510,30800264）,江苏省博士后基金项目（1002083c）,南京军区重点医药卫生项目（072030）,南京军区南京总医院基金项目（Q2008063）

作者：陈春晓[1], 郭超[1], 郑罡[2,3], 王利[2,3], 赵铁柱[2,3], 卢光明[1,2]

关键词：动脉自旋标记, 磁共振成像, 脑血流量, 静息态, Artedal spin labeling technique, Magnetic resonance imaging, Cerebral blood flow, Resting state

中文摘要：

比较研究了脉冲式动脉自旋标记（pulsed arterial spin labeling，PASL）和伪连续武动脉自旋标记（pseudo continuous arterial spin labeling，pCASL）两种磁共振成像技术在静息态脑灌注中的应用。在静息态下，采用两种动脉自旋标记技术采集了10例健康志愿者的脑灌注数据，并计算脑血流量。两种技术的测量结果均显示，人脑默认网络中的楔前叶、角回、岛叶和后扣带回的相对脑血流量高于全脑平均灌注，而pCASL更敏感。在白质、额叶、顶叶、小脑和小脑蚓区域，pCASL和PASL测量得到的灌注值有显著性差异，除枕叶、小脑和小脑蚓外，PASL测量得到的灌注量小于pCASL。在全脑范围内，pCASL的信噪比明显高于PASL，且负灌注量很少。实验表明，pCASL可以提供比PASL更准确的测量结果。

英文摘要：

The comparative study between pulsed artedal spin labeling （PASL） and pseudo continuous arterial spin labeling （pCASL） in resting cerebral perfusion were investigated. The PASL and pCASL data of 10 healthy subjects were acquired by a 3.0 T MR scanner during resting state, and the relative cerebral blood flows （rCBF） were then respectively quantified and analyzed. The results revealed that both techniques were able to detect the rCBF. CBFs in the precuneus, angular gyrus, insula, posterior cingulate cortex in default network were higher than the mean CBF in the whole brain, and pCASL was much more sensitive. Comparison with PASL sequence, CBFs obtained by the pCASL were significantly higher in white matter, frontal and parietal lobe, cerebellum and cerebellar vermis than that of PASL. Moreover, in the whole brain, higher SNR and less negative perfusion voxels were found in pCASL. The experimental results show that pCASL provides more accurate measurements than PASL in cerebral blood flow perfusion.

同期刊论文项目