中文摘要：

比较栀子大黄汤中芦荟大黄素，大黄酸，大黄酚及大黄素甲醚在正常、酒精肝损伤大鼠药代动力学过程。给予大鼠灌服50％乙醇，连续十天，建立酒精肝损伤模型。采用HPLC－FLD法测定大鼠灌服栀子大黄汤不同时间点蒽醌血药浓度。模型组中芦荟大黄素、大黄酸、大黄酚、大黄素甲醚Cmax， AUC0～t显著低于正常组（P＜0.05）。酒精所致肝损伤能够阻碍栀子大黄汤中蒽醌成分的吸收，降低血浆暴露率。

英文摘要：

To compare the pharmacokinetics of aloe-emodin, rhein, chrysophanol, physcion from Zhi-Zi-Da-Huang Decoction （ ZZDHD） in normal, alcohol induced hepatic injury rats.Alcohol induced liver injury rat model was established by oral administration of 50%ethnol for ten days.The plasma concentration of anthraquinones at difffetent time was determined by HPLC-FLD method.A significant decrease （ P＆lt;0.05 ） in Cmax and AUC values for aloe-emodin, rhein, chrysophanol, physcion as observed in model group compared with normal group.Acohol-induced liver injury can hinder gastrointestinal absorption and lower plasma exposure rate of anthraquinones.