中文摘要：

建立栀子大黄汤中绿原酸含量测定方法，比较不同配伍条件下绿原酸溶出差异，探寻溶出规律。 Lichrospher C18（4.6 mm ×250 mm，5μm）色谱柱，甲醇－0.5％乙酸，流速为1 mL／min，柱温30℃，检测波长：325 nm。栀子与大黄配伍后绿原酸溶出量较单味栀子增加33.33％，全方配伍后绿原酸溶出量则降低20.8％。复方配伍对绿原酸的溶出有一定的影响。

英文摘要：

A method for the determination of chlorogenic acid in ZZDHD was established and the different dissolution in different compatibility was compared, the dissolution characteristics were explored.Lichrospher C18 column （4.6 mm× 250 mm, 5 μm） , methanol-0.5% acetic acid, flow rate was 1 mL/min, column temperature was 30 ℃, wavelength was 325 nm.The content of chlorogenic acid increased 33.33% after the compatibility of gardenia with rhubarb, while decreased 20.8% in ZZDHD.Different combinations of complex prescription of Chinese herbal medicine had great influence on the dissolution of chemical component content.