欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的：评价IFN-γ基因多态性与哮喘易感性的关系。方法：检索中文及外文数据库，全面收集2012年3月之前发表的研究IFN-γ基因多态性与哮喘相关性的病例对照研究，对采纳的数据进行Meta分析。结果：21篇文献被纳入分析，其中5篇文献涉及基因位点＋874T／A（rs2430561），累积病例381例。Meta分析计算合并比值比（95％可信区间）：AA／TT＋TA基因型为1．63（1．06～2．49）。AA／TT＋TA研究数据不存在发表偏倚（P=0．271）。结论；当前的研究支持IFN-γ＋874位点基因型AA可能是哮喘发病的危险因素。＋874位点基因型TT和TA与哮喘发病尚无明确关系。
英文摘要：
Objective： To investigate the association between the polymorphism of IFN-γ gene and the genetic suscepti- bility to asthma. Methods： Correlative bibliographic database and academic publication of internal and abroad were re- trieved, which were published before the March 2012. Meta-analysis was performed to determine whether the polymor- phism of IFN-γ gene was associated with asthma. Results： Twenty-one literatures were retrieved, and 5 of them were involved in the gene locus ＋874T/A （rs2430561） in IFN-7 gene including total cumulative 381 cases. The odds ratio for asthma for AA/TT＋TA genotypes was 1.63（95%CI 1.06-2. 49）. No significant publication bias was found re- garding AA/TT＋TA genotypes（P=0. 271）. Conclusion： ＋874AA genotype of IFN-γ gene might be the risk factors for asthma, whereas TT and TA genotypes of IFN-γ gene were no clear relationship with asthma.
同期刊论文项目
同项目期刊论文
Morphologic features of Sancassania berlesei (Acari: Astigmata: Acaridae), a common mite of stored p
Genetic diversity and differentiation of Lepidoglyphus destructor (Acari: Glycyphagidae) inferred fr
Production of a chimeric allergen derived from the major allergen group 1 of house dust mite species
期刊信息
位置：