中文摘要：

目的通过对比研究同一批焦炉工人焦炉逸散物暴露5年前后肺通气功能的损伤情况，进一步探讨焦炉逸散物与焦炉工人肺通气功能损伤的关系。方法选取山西某焦化厂焦炉作业工人165人（暴露组）和辅助工人52人（对照组）为研究对象，使用统一调查表收集工人个人信息。定点定期采集工作场所中空气样本，高压液相色谱仪测定空气样本中苯并（a）芘浓度。分别于2009和2013年使用便携式肺功能仪测定研究对象肺通气功能，并进行对比分析。结果2009至2013年同一区域B（a）P浓度的差异无计学意意义（P〉0．05）。与2009年比较，2013年对照组工人各肺功能测定值及异常率差异无统计学意义（P〉0．05），而暴露组工人用力肺活量（FVC％）、第1秒用力呼气容积（FEV1.0％）、最大通气量（MVV％）、肺活量（VC％）、25％肺活量时呼气流速（FEF25％）均显著降低，FVC％、FEV1.0%和VC％异常率显著升高，差异有统计学意义（P〈0．05）。新出现肺功能异常的工人主要分布在炉顶和炉侧，炉顶组FVC％、FEV1.0扬、VC％新增异常人数（率）明显高于对照组和炉底组，炉侧组明显高于对照组，差异有统计学意义（P〈0．05）。多因素logistic回归分析结果显示，继续暴露5年后，炉顶作业工人FVC％、FEV1.0%和VC％新出现肺功能异常的调整OR分别为7．939、5．966和4．956；接焦工龄为暴露组工人FVC％、FEV1.0％、MVV％、VC％异常的危险因素。接焦工龄与炉顶作业存在正向交互作用，差异有统计学意义（P〈0．05）。结论焦炉工人肺功能损伤与焦炉逸散物暴露有关，焦炉逸散物暴露水平和暴露时间是焦炉工人肺功能损伤的主要影响因素，二者存在正交互作用。

英文摘要：

Objective Through comparative study on pulmonary function damage of coke oven workers exposed to coke oven emissions with the same group before and after five years , and further explore the relationship between the coke oven emissions and injury in pulmonary function of coke oven worker. Methods Select a eoking plant in Shanxi 165 coke oven workers （exposed group） and 52 auxiliary workers （control group） for the study, using a uniform questionnaire to collect workers＇ personal information. Fixed workplace air samples collected periodically. Air samples of benzo （a） pyrene concentrations was measured by high pressure liquid chromatograph. Pulmonary function of research object was measured by portable spirometer respectively in 2009 and 2013, and comparative analysis on it. Results The concentration of B（a）Pwas no significant difference in the same area between 5 years in 2009-2013. Compared with 2009, 2013 control workers lung function index and the abnormal rate had no significant difference （P〉0.05）. But FVC%, FEV1.0%, MVV% , VC% and FEF25% of exposed workers in 2013 was significantly lower than in 2009, FVC%, FEV1.0%, VC% and FEF25% pulmonary dysfunction rate in 2013 was also significantly higher than in 2009, difference was statistically significant （P〈0.05）. Workers emerging pulmonary function abnormalities mainly distributed in furnace roof and side. furnace roof group FVC%, FEV1.0%, VC% additional abnormal number （rate） was significantly higher than furnace floor and the control group （P〈0.05）, and furnace side groop was significantly higher than the control group, the difference was statistically significant （P〈0.05）. Multivariate Logistic regression analysis showed that after 5 years FVC%, FEV1% and VC% of abnormal lung function emerging adjusted OR of furnace roof workers were 7.939, 5.966 and 4.956. For abnormal of FVC%, FEV1% ,VC% and MVV%, the contacting coke seniority is a risk factor. There is a positive interaction between contacting coke seniority and