中文摘要：

目的 通过分析年龄和尿1-羟基芘（1-OHP）及其交互作用与焦炉工人高血压患病率的关系,进一步探讨焦化工人高血压发病的可能机制。方法 选取山西某焦化厂343名焦化作业工人为研究对象,使用统一的调查表收集个人基本信息,静息状态下检测血压3次,高效液相色谱仪检测研究对象尿1-OHP浓度。结果按尿1-OHP浓度三分距法将研究对象分为低暴露组（≤1.52μmol/mol Cr）、中暴露组（〉1.52-3.88μmol/molCr）和高暴露组（≥3.88μmol/mol Cr）,高血压患病率分别为13.6%、17.5%和27.7%,其中高暴露组高血压患病率显著高于低暴露组,差异有统计学意义（P〈0.05）;多因素Logistic回归分析结果显示,〉35岁与高暴露为高血压的危险因素,二者存在超相乘模型的正向交互作用,OR（95%CI）为6.800（2.344,19.729）,交互系数r=2.556。结论焦炉工人〉35岁年龄和高暴露尿1-OHP为焦炉工人高血压的危险因素,且年龄与尿1-OHP及其蓄积作用均存在正交互作用。

英文摘要：

Objective To determine the correlation between the age and urinary 1-hydroxypyrene （1-OHP） and its interaction with the prevalence of hypertension in coke-oven workers, and to investigate the possible mechanism of hypertension in coke-oven workers. Methods A total of 343 coke-oven workers in a coking plant in Shanxi Province were included as the subjects. A unified questionnaire was used to collect personal information. The blood pressure at the resting state was measured 3 times. The concentration of urine 1-OHP was determined by high performance liquid chromatography （HPLC）. Results The subjects were divided into low exposure group （≤ 1.52 μmol/molCr）, middle exposure group （〉1.52-3.88 μmol/molCr） and high exposure group （≥3.88 μmol/molCr） according to the urine 1-OHP concentration. The prevalence of hypertension was 13.6%, 17.5% and 27.7%, respectively. The prevalence of hyper- tension in the high exposure group was significantly higher than that in the low exposure group, and there was statistically significant difference （P〈0.05）. Multivariate logistic regression analysis showed that 〉35 years of age and high exposure were the risk factors of hypertension, and there was positive interaction of muhiplicative model between them. The OR （95% C/） was 6.800 （2.344, 19.729）, interaction coefficient r=2.556. Conclusion Over 35 years of age and 1-OHP exposure are the risk factors of hypertension in coke-oven workers. There is positive interaction between age and urinary 1-OHP and its accumulation.