中文摘要：

摘要：目的研究焦炉工人尿1-羟基芘（1-OHP）及其蓄积作用与肺通气功能损伤的关系。方法于2009年6—7月选取某焦化厂185名焦炉作业工人为暴露组，同厂辅助工种145人为对照组。使用统一的调查表收集个人基本信息，采用高效液相色谱法检测作业环境空气中苯并（a）芘和研究对象尿1-OHP浓度，采用肺功能仪测定肺功能指标。结果暴露组工人25％肺活量时呼气流速（FEF25）、肺活量（VC）、用力肺活量（FVC）、第1秒用力呼气容积（FEV1）均低于对照组，差异有统计学意义（P〈0．05）。以尿1-OHP浓度2．3μmol／molCr为界值将暴露组分为高暴露和低暴露，高暴露组75％肺活量时呼气流速（FEF75）、FEF25、VC、FVC、FEV1均低于低暴露组，差异有统计学意义（P〈0．05）。多重线性逐步回归分析结果显示，暴露组尿1-OHP浓度与50％肺活量时呼气流速（FEF50）、FEF25、最大呼气流速（PEF）、VC、MVV、FEV1呈负相关（P＜0．05），尿1-OHP的蓄积作用与VC、FVC、MVV、FEV1呈负相关（P〈0．05）。结论焦炉工人尿1-OHP及其蓄积作用与肺功能损伤有关，可用来反映焦炉工人肺功能损伤情况。

英文摘要：

Objective To understand the relationship between urinary 1-hydroxypyrene （1-OHP） concentrations and lung function injury in coke-oven workers. Methods A total of 185 coke-oven workers were selected as the exposure groups and 145 unexposed workers were selected as the control group. The general information was collected through uniform questionnaire. 1-OHP in urine was measured by HPLC. Lung function indicators were determined by using portable spirometer. Results FEF25, VC, FVC, and FEV1 in the coke-oven group were significantly lower compared with those of control group. The exposed workers were divided into high and low exposure groups based on 2.3 μmol/mol Cr of 1-OHP, and FEF75, FEF25, VC, FVC and FEV1 in the high exposure group were significantly lower than those in the low exposure group. In the coke-oven group, the level of urinary 1-OHP was negatively correlated with FEF50, FEF25, PEF, VC, MVV and FEV1 （P〈0.05）. The urinary accumulation of 1-OHP was negatively correlated with VC, FVC, MVV and FEV1. Conclusion The urinary 1-OHP level and the accumulation of 1-OHP can be used to detect the early lung function injury in coke-oven workers.