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Oxygen transfer in human carotid artery bifurcation
  • 期刊名称：Acta Mech Sin
  • 时间：0
  • 页码：305-309
  • 语言：中文
  • 分类：Q66[生物学—生物物理学]
  • 作者机构：[1]Dalian University of Technology, Dalian 116023, China, [2]Department of Bioengineering, Beihang University,Beijing 100083, China
  • 相关基金：The project supported by the National Natural Science Research Council of China （10632010, 10572017, 30670517）.Acknowledgments The software is provided by ANSYS corporation, USA.
  • 相关项目：动脉系统中的旋动流现象-它对血小板运动、粘附和物质（LDL）输运的影响及其在临床中的应用
作者： 张治国|邓小燕|樊瑜波|
关键词： 动脉粥样硬化, 颈动脉, 质量传递, 二次流, Atherosclerosis, Carotid artery , Secondary flow , Mass transfer
中文摘要：

动脉的分叉是血流动可以被扰乱的地方，慢再通行流动可以发生。揭示在本地氧转移和 atherogenesis 之间的关联，一个有限元素方法被采用在人的颈动脉动脉分叉模仿血流动和氧转移。在稳态流条件下面，数字模拟在分叉在本地氧转移表明了一个变化，证明在扰乱的流动区域的对流条件可以生产在血 / 墙接口的不平的本地氧转移。有在颈动脉湾穴的慢旋涡的形成的扰乱的血流动在湾穴的入口在氧供应导致了消沉到动脉的墙，它可以接着导致动脉的墙的 atherogenic 回答，并且贡献在那里的动脉粥样硬化患者狭窄的发展。

英文摘要：

Arterial bifurcations are places where blood flow may be disturbed and slow recirculation flow may occur. To reveal the correlation between local oxygen transfer and atherogenesis, a finite element method was employed to simulate the blood flow and the oxygen transfer in the human carotid artery bifurcation. Under steady-state flow conditions, the numerical simulation demonstrated a variation in local oxygen transfer at the bifurcation, showing that the convective condition in the disturbed flow region may produce uneven local oxygen transfer at the blood/wall interface. The disturbed blood flow with formation of slow eddies in the carotid sinus resulted in a depression in oxygen supply to the arterial wall at the entry of the sinus, which in turn may lead to an atherogenic response of the arterial wall, and contribute to the development of atherosclerotic stenosis there.

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