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紫苏叶注射液对犬血管搭桥术后犬的血液流变学影响

ISSN号：0529-6005
期刊名称：《中国兽医杂志》
时间：0
分类：S853.74[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
作者机构：[1]贵州大学动物科学学院动物医学系,贵州贵阳550025, [2]新乡医学院生命科学技术系,河南新乡453003, [3]北京航空航天大学生物与医学工程学院,北京海淀100083
相关基金：国家自然科学基金项目（10572029,10772054）;国家自然科学基金重点项目（10632010）

作者：徐在品[1], 毕彦平[2], 高俊波[1], 王清宇[1], 罗鹏[1], 赵伟[1], 王定坤[1], 彭尧[1], 邓小燕[3]

关键词：紫苏叶注射液, 血管搭桥, 血液流变学, 犬, Folium Perillae injection, hemorrheology, bypass vascular surgery, canine

中文摘要：

目的：探讨紫苏叶注射液对犬动脉搭桥术后血液流变学参数的影响。方法：将20只试验犬随机分为高、中、低剂量组（1434mg／kg，478mg／kg，159mg／kg）及对照组，采用同侧自体颈外静脉重建颈总动脉，术后头静脉滴注紫苏叶注射液，持续给药3周，分别于给药前、给药后第1周、第2周和第3周测定血液流变学各项参数。结果：与用药前比较，低、中、高剂量紫苏叶注射液均能显著或极显著降低低切（10s^-1）时全血黏度、全血还原黏度、红细胞聚集指数和红细胞电泳指数（P〈0．05，P〈0.01）；高剂量紫苏叶注射液能显著降低中切（60s^-1）时全血黏度、全血还原黏度（P〈0．05），但低剂量和中剂量紫苏叶注射液对中切（60s^-1）时全血黏度、全血还原黏度无显著影响（P〉0．05）；低、中、高剂量紫苏叶注射液对高切（150s^-1）时全血黏度、全血还原黏度、红细胞变形指数、红细胞刚性指数、血浆黏度和红细胞压积无显著影响。结论：紫苏叶注射液能明显改善搭桥术后犬的血液流变学参数，降低血液黏度。

英文摘要：

Objective： To explore the effects of Folium Perillae injection on blood parameters after vascular bypass surgery in dogs. Method： Twenty hybridization dogs were randomly divided into high, middle, low dosage groups （1 434 mg/kg,478 mg/kg,159 mg/kg）and control. The common carotid artery was reconstructed with jugular vein from the same side by 45° bypass vascular surgery. Folium Perillae injection was intravenously administrated from brachiocephalic vein daily for 3 weeks. The blood parameters were detected at the 0, 1, 2, and 3 weeks after drug administration. Results.. Compared with the control group, low, medium and high dosage of Folium Perillae injection could significantly decrease the whole blood viscosity and the whole blood reductive viscosity at low shear rate（10 s^-1 ）, erythrocyte aggregation index and erythrocyte electrophoresis index （P〈0.05 or P〈0.01）. High dosage of Folium Perillae injection could significantly decrease the whole blood viscosity and the whole blood reductive viscosity at middle shear rate（60 s^-1 ）（P〈0.05）, but low and middle dosage of Foliurn Perillae injection had no significant effects on the whole blood viscosity and the whole blood reductive viscosity at medium shear rate（60 s^-1 ）（P〉0.05）. Low, middle and high dosage of Folium Perillae injection had no significant effects on hematocrit, plasma viscosity, erythrocyte rigidity index, the whole blood viscosity and the whole blood reductive viscosity at high shear rate （150 s^-1 ）. Conclusions. Folium Perillae injection could significantly improve the hemorrheological characteristics of dogs after vascular bypass surgery.

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