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中文摘要：
选取10条雄性健康犬，随机分成对照组和治疗组，每组5条。实验动物模型采用同侧自体颈静脉行颈动脉45°搭桥。术后均采取常规治疗，治疗组给予肝素钠。分别于术前及术后1、2、3天在颈静脉采血，检测D－二聚体、血清纤维蛋白（原）降解产物（FDP）、血浆血小板α颗粒膜蛋白（GMP－140）、纤溶酶原激活剂的抑制物－1（PAI－1）和组织纤溶酶原激活剂（t—PA）等纤维蛋白溶解系统（纤溶）指标的变化。结果：治疗组与对照组相比，D－二聚体、GMP－140、PAI－1显著降低（P〈0．05），t—PA显著升高（P〈0．05），FDP变化不显著（P〉0．05）。结论：肝素钠可改善血管搭桥术后纤溶系统，纠正血液高凝状态，恢复抗凝系统活性。
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