趋化因子通过与其受体的相互作用,招募外周血中的淋巴细胞到达肝脏炎症部位,介导HBV感染后的病毒清除与免疫损伤的过程.此文就趋化因子IFN诱导蛋白10(IP-10)、LFN-γ诱生单核因子(MIG)、IFN诱导T细胞趋化因子(I-TAC)及其共同受体CXCR3在慢性乙型肝炎发病中的作用进行综述.
Chemokines recruit lymphocytes from peripheral blood by interacting with their receptors,which mediate the viral clearance and immunologic injury in chronic hepatitis B.The role of chemokine interferon-inducible protein-10(IP-10),monokine induced by gamma interferon(MIG),IFN-inducible T cell alpha chemoattractant(I-TAC) and their co-receptor CXCR3 are briefly reviewed.