中文摘要：

目的 了解雌激素受体α基因XbaI和PvuII多态性与乙型肝炎病毒感染慢性化的关系，从基因水平上探讨慢性乙型肝炎的发病机制。方法 采用聚合酶链反应-限制性片段长度多态性法检测93例乙型肝炎病毒感染恢复期患者和169例慢性乙型肝炎患者雌激素α受体基因PvuII和XbaI多态性。结果 慢性乙型肝炎患者雌激素受体基因PvuII多态性的C／T基因型和c等位基因频率（52．7％，44．1％）明显高于乙型肝炎病毒感染恢复期患者（37．6％，29．6％）；TT基因型和T等位基因频率（29．5％，55．9％）明显低于后者（47．3％，70．4％），差异有统计学意义（P〈0．05）；CT＋CC基因型乙型肝炎病毒感染慢性化的风险是TT基因型的2．54倍（OR=2．539，CI：1．50～4．29）。雌激素受体基因XbaI多态性分布在慢性乙型肝炎患者和乙型肝炎病毒感染恢复期患者间比较，差异均无统计学意义（P〉0．05）。结论 雌激素受体基因PvuII C/T基因型和C等位基因可能是乙型肝炎病毒感染慢性化的遗传易感基因。

英文摘要：

Objective To investigate the relationship between estrogen receptor α gene polymorphisms and chronic HBV infection. Methods XbaI and PvuII polymorphisms of estrogen receptor α （ESR1） gene were analyzed in 169 patients with chronic HBV infection and in 93 patients recovered from HBV infection by polymerase chain reaction-restriction fragment length polymorphism technique. Results The frequencies of CT genotype and C allele of ESR1 gene in patients with chronic HBV infection were higher than those in control group patients （52.7%,44.1% vs. 37.6%,29.6%）, while the frequencies of TT genotype and T allele of ER1 gene in patients with chronic HBV infection were lower than those in control group patients （29.5%,55.9% vs. 47.3%,70.4%,P〈0.05）. The risk of chronic infection occurrence in patients with CT and CC genotype was 2.54 folds than that in patients with TT genotype （OR=2.539,CI：1.50 to 4.29）. There was no significant difference in frequencies of allele and genotype in XbaI polymorphisms among the chronic HBV infection group and control group （P〉0.05）. Conclusion CT genotype and C allele might be the susceptibility gene for chronic HBV infection.