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Stochastic responses of tumor-immune system with periodic treatment
  • ISSN号:1674-1056
  • 期刊名称:《中国物理B:英文版》
  • 时间:0
  • 分类:O324[理学—一般力学与力学基础;理学—力学] Q279[生物学—细胞生物学]
  • 作者机构:[1]College of Data Science, Taiyuan University of Technology, Taiyuan 030024, China, [2]College of Mathematics, Taiyuan University of Technology, Taiyuan 030024, China
  • 相关基金:Project supported by the National Natural Science Foundation of China(Grant Nos.11402157 and 11571009); Shanxi Scholarship Council of China(Grant No.2015-032); Technological Innovation Programs of Higher Education Institutions in Shanxi,China(Grant No.2015121); Applied Basic Research Programs of Shanxi Province,China(Grant No.2016021013).
中文摘要:

我们与环境噪音和周期的处理调查一个肿瘤免疫者系统比赛模型的随机的回答。第一,在外部变化下面描述在肿瘤房间和免疫系统之间的相互作用的一个数学模型和周期的治疗基于随机的微分方程被建立。然后,为肿瘤房间的扑灭和坚持的足够的条件被构造 Lyapunov 功能和 Itos 公式导出。最后,数字模拟被介绍说明并且验证结果。这个工作的结果为设计更有效、精确的治疗学的策略消除癌症房间提供理论基础,特别为联合免疫疗法和传统的工具。

英文摘要:

We investigate the stochastic responses of a tumor–immune system competition model with environmental noise and periodic treatment. Firstly, a mathematical model describing the interaction between tumor cells and immune system under external fluctuations and periodic treatment is established based on the stochastic differential equation. Then, sufficient conditions for extinction and persistence of the tumor cells are derived by constructing Lyapunov functions and Ito's formula. Finally, numerical simulations are introduced to illustrate and verify the results. The results of this work provide the theoretical basis for designing more effective and precise therapeutic strategies to eliminate cancer cells, especially for combining the immunotherapy and the traditional tools.

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期刊信息
  • 《中国物理B:英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国物理学会和中国科学院物理研究所
  • 主编:欧阳钟灿
  • 地址:北京 中关村 中国科学院物理研究所内
  • 邮编:100080
  • 邮箱:
  • 电话:010-82649026 82649519
  • 国际标准刊号:ISSN:1674-1056
  • 国内统一刊号:ISSN:11-5639/O4
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:406