中文摘要：

研制了盐酸格拉司琼离子选择性电极。利用正交设计法综合研究了活性物质的含量以及增塑剂等因素对PVC膜电极响应性能的影响。结果表明，以盐酸格拉司琼一四苯硼钠离子缔合物（膜中含量为4．8％）为活性物质，邻苯二甲酸二辛酯为增塑剂制成的PVC膜电极的性能最佳。该电极在5．0×10—2～1．0×10—5mol·L-1范围内呈现能斯特响应，斜率为58．7mV／pc，检测下限为8．0×10—6mol·L-1。该电极可直接用于盐酸格拉司琼片剂的含量测定，回收率为99％～102％，其结果与高效液相色谱法一致。

英文摘要：

A granisetron hydrochloride selective electrode is prepared based on granisetron-tetraphenylboron as a carrier . Orthogonal methodology is adapted for studying the impacts of active substance content and Plasticizer on response performance of PVC Membrane Electrode. The option of Granisetron hydrochloride- Sodium Tetraphenylboron Ion-Association Compounds（4.80/oo in membrane） as active substance and Di-n- octyl phthalate（DOP） as Plasticizer is the best scheme. A fast near-Nernstian response is shown for granisetron of 5.0×10-2--1.0×10-5 mol · L-1 with the slope of 58.7 mV/decade. The detection limit is 8.0 × 10.6 mol ·L -1 and the electrode can be used for potentiometric determination of granisetron hydrochloride tablets directly. The recovery range is 990%- 102% which is in agreement with those determined by the method in the Pharmacopoeia.