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中文摘要：
采用固相有机合成技术定向设计合成多种两亲基团有机小分子化合物,该类化合物既含有氨基（或氨基乙酸基）取代的糖基亲水基团又含有不同链长脂肪酯憎水基团。在缓冲介质中这些有机小分子的糖基亲水基团之间通过氢键及范德华力作用相互聚积，脂肪链酯憎水基团之间通过疏水作用相互堆积自组装形成含有纳米级大小的亲水性和憎水性分隔区室的三维网状结构的超分子纳米水胶。该超分子水胶具有良好的生物兼容性和机械性能，高含水量的亲水区室可保持蛋白质活性，而憎水区室能直接固载脂溶性电子媒介体。通过分子中的氨基在三维网状结构的超分子水胶内外自组装金属纳米微粒提高抗体蛋白及电子媒介体的固载，研制出高灵敏、快响应、长寿命、低成本多种重要传染病及肿瘤标志物免疫传感器用于临床诊断及生物制品检测。灵活多变的分子设计合成还可制备特异性超分子纳米水胶生物材料用于医药诊疗、蛋白质表达、DNA和酶传感器研究。
结论摘要：
英文主题词immunosensor, supermolecule nano-hydrogel, nanomaterials
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期刊论文
Enhancement of carcinoembryonic antibody immobilization on gold electrode modified by gold nanoparti
Probing traces of hydrogen peroxide by use of a biosensor based on mediator-free DNA and horseradish
Amplification of antigen–antibody interactions via back-filling of HRP on the layer-by-layer self-as
A novel amperometric immunosensor based on layer-by-layer assembly of gold nanoparticles–multi-walle
Investigation of the electrochemical and electrocatalytic behavior of positively charged gold nanopa
New Antibody Immobilization Strategy Based on Gold Nanoparticles and Azure I/Multi-Walled Carbon Nan
Core/shell magnetic CoFe2O4/SiO2 porous composite nanoparticles as immobilized affinity supports for
Magnetic Control of an Electrochemical Microfluidic Device with an Arrayed Immunosensor for Simultan
Quartz crystal microbalance immunoassay for carcinoma antigen 125 based on gold nanowire-functionali
Layer-by-layer self-assembled multilayer films of multi-walled carbon nanotubes and platinum–Prussia
Reagentless Electrochemical Hydrogen Peroxide Biosensor Based on Toluidine Blue-Derived Organic Mate
Direct electrocatalytic reduction of hydrogen peroxide based on Nafion and copper oxide nanoparticle
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