中文摘要：

为研究头霉素C（1）产生菌链霉菌Streptomycin sp.OFR1022的发酵工艺,并提高1的产量,首先在单因素试验的基础上确定显著影响因素及其含量水平,再利用响应面分析法中的Box-Behken中心组合试验设计,优化产1发酵培养基中的显著影响因素,用Design Expert 8.0软件分析结果,得到较优培养基配方.在该条件下,1产量为l 905.6 μg/ml,较优化前提高了68.3％,与预测值（1 984.03 μg/ml）的相对误差为3.95％.

英文摘要：

The main notable factors of the fermentation medium for Streptomycin sp. OFR1022 producing cephamycin C （1） were optimized by one factor at-a-time method and Box-Behken design for response surface methodology to optimize the fermentation technology as well as to increase the productivity of 1. The experimental results were examined through regression analysis by Design Expert 8.0. Finally, the optimal medium was obtained and the production of 1 reached to 1 905.6 ug/ml, a 68.3 % increase compared to that of the original medium, with a relative error of 3.95 % to the predicted value （1 984.03 ug/ml）.