中文摘要：

目的：研究南海红树林内生真菌SK7RN3G1的代谢产物。方法：采用反复硅胶柱色谱法、Sephadex LH-20凝胶色谱法等进行分离纯化,并通过理化常数测定和光谱分析鉴定其化学结构。结果：从南海红树林内生真菌SK7RN3G1的菌体中分离得到6个代谢产物。经波谱解析,分别为：3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate（1）,lichenxanthone（2）,griseoxanthone C（3）,1,3,6-trihydroxy-8-methyl-9H-xanthen-9-one（4）,harman（1-甲基-β-咔啉）（5）,N9-甲基-1-甲基-β-咔啉（6）。初步药理活性显示化合物1和2对人体肝癌细胞HepG2抑制的IC50分别为20,25 mg.L-1。根据文献报道,化合物5具有抗HIV活性,其EC50为10.7μmol.L-1,化合物6具有抗HIV和抗癌重要生理活性。结论：所有化合物均首次从南海红树林内生真菌SK7RN3G1中分离得到。

英文摘要：

Objective： To study on secondary metabolites of mangrove endophytic fungus No-SK7RN3G1 from the south china sea. Method： The compounds were isolated by column chromatography and identified on the basia of physic-chemical constants and spectral analysis. Result： Six metabolites were obtained and elucidated as 3, 8-dihydroxy-6-methyl-9-oxo-9H-xanthene-l-carboxylate （1）, lichenxanthone （2）, Griseoxanthone C （3）, 1, 3, 6-trihydroxy-8-methyl-9H-xanthen-9-one （4）, harman （ 1 -methyl-β-carboline） （ 5 ）, N9- methyl -1 - methyl - β- carboline （6）. In the preliminary bioassay, 1 and 2 show inhibittory activity on the HepG2 cell line with IC5o values of 201xg/mL and 25μg/mL, respectively. According to the literatures, 5 shows anti HIV activity with ECso values of 10.7 txmol · L^（-1）, 6 hasimportant physiological activity of anti HIV and anticancer. Conclusion： The six metabolites were obtained from endophytic fungus No.SK7RN3G1 for the first time.