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中文摘要：
目的：测定复发性流产（RSA）患者绒毛中TNF—α、IL-6水平，探讨TNF-α和IL-6与复发性流产发生的关系。方法：采用实时荧光定量逆转录多聚酶链式反应（RQRT—PCR）方法测定62例复发性流产患者、50例正常早孕妇女绒毛组织中TNF-α、IL-6的表达水平。结果：与正常早孕妇女相比，复发性流产患者绒毛组织中TNF—α水平明显增高（P〈0．01），IL-6水平明显降低（P〈0．01），且两者水平呈负相关性（r=-0．433，P〈0．05）。复发性流产患者绒毛组织中TNF-α水平，IL-6水平、流产次数与正常早孕妇女比较无统计学差异（P〉0．05）。结论：TNF—α和IL-6可能参与了复发性流产的发病过程。
英文摘要：
Objective： To explore the levels of tumor necrosis factor -α（ TNF - α） and interleukin - 6 （ IL - 6） in villi of patients with recurrent spontaneous abortion （RSA） , explore the relationship between TNF - α, IL - 6 and RSA. Methods： Real - time fluorescent quantitative reverse transcriptase polymerase chain reaction （ RQ RT - PCR） was used to detect the expression levels of TNF - α and IL- 6 iti vill6us tissues of 62 patients wi（h RSA and 50 normal women of early pregnancy. Results： Compared with normal women of early pregnancy, the level of TNF - ct in villous tissue of RSA patients increased significantly （ P 〈 0. 01 ）, the level of IL - 6 decreased signifi- cantly （ P 〈 0. 01 ）, and there was a negative correlation between TNF - α expression level and IL - 6 expression level （ Y = - 0. 433, P 〈 0. 05 ） . There was no statistically significant difference in the levels of TNF - α and IL - 6, the times of abortion between RSA patients and normal women of early pregnancy （ P 〉 0. 05 ） . Conclusion： TNF - α and IL - 6 may be involved in the pathogenesis of RSA.
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