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中文摘要：
目的：研究白细胞介素-6（IL-6）和白细胞介素-18（IL-18）在复发性流产（RSA）患者绒毛组织中的表达，探讨RSA的发病机制。方法采用实时荧光定量逆转录聚合酶链反应技术，检测63例RSA妇女（RSA组）及50例正常早孕妇女（正常组）绒毛组织中IL-6mRNA和IL-18mRNA的表达水平，并将两者进行相关性分析。结果RSA组绒毛组织中IL-6mRNA的表达水平显著低于正常组，IL-18mRNA水平显著高于正常组，相关分析显示，RSA组IL-6与IL-18mRNA两者之间表达水平呈负相关（r=-0．49，P〈0．01）。IL-6mR—NA的表达水平与RSA患者流产次数无关，而IL-18mRNA表达水平随着流产次数增多而增加，差异有统计学意义（P〈0．05）。结论正常妊娠较RSA患者绒毛组织IL-6水平高，当IL-6表达降低或IL-18升高时，可能导致RSA，其中IL-18水平与流产次数呈正相关。
英文摘要：
Objective To investigate the expression of interleukin -6 （IL -6） and interleukin -18 （IL - 18） mRNA in villi of patients with recurrent spontaneous abortion （RSA） and to investigate the pathogenesis of RSA. Methods Real - time quantitative reverse transcription - polymerase chain reaction was used to quantify the expression of IL - 6 mRNA and IL -18 mRNA in villi of 63 patients with RSA （RSA group） and 50 normal early pregnant women（ normal group）. The correlation between IL- 6 and IL- 18 was analyzed. Results IL- 6 mRNA was significantly lower, while IL - 18 mRNA was significantly higher, in RSA group than that in normal group. Meanwhile, there was significantly nega- tive correlation between the IL- 6 and IL- 18 in RSA group （r = -0. 49, P 〈0. 01 ）. Although there was no significant correlation between the number of abortion and IL- 6 mRNA, IL- 18 mRNA was significantly elevated with the increase of number of abortion （ P 〈 0. 05 ）. Conclusion The down - regulated IL - 6 or up - regulated IL - 18 can lead to RSA, as IL - 18 is furthermore positively correlated with the number of abortion.
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