调节性T细胞(Regulatory Tcells,Tregs)是一类有别于Th1和Th2细胞的具有免疫抑制功能的CD4+T淋巴细胞,在维持机体免疫稳态和免疫耐受中发挥重要作用。研究表明,蠕虫感染能诱导Tregs产生,Tregs通过抑制局部效应性T细胞的功能,降低蠕虫感染对宿主造成的免疫病理损伤。
Regulatory T cells (Tregs), a class of CD4+ T lymphocytes which are different from the Thl and Th2 lymphocytes, have immunosuppressive function and play an important role in maintaining immune homeostasis and im- mune tolerance. Previous studies showed that the generation of Tregs could be induced, and Tregs reduced the immune pathological damage to the host by inhibiting T-cell function in helminth infection.