中文摘要：

目的：探讨胰岛素样生长因子Ⅱ mRNA结合蛋白3（IMP3）在平滑肌肉瘤及平滑肌瘤中的表达及意义。方法：应用免疫组化sP法观察IMP3在15例平滑肌肉瘤患者中的表达情况及与临床病理特征的关系，同时选取54例平滑肌瘤患者作为对照。结果：IMP3在平滑肌肉瘤患者中的阳性表达率为73．33％（11／15），IMP3在子宫组、中低分化组、肿瘤性坏死组、核分裂计数〉125个／10HPF组及ki67〉20％组的阳性表达率高于子宫外组、高分化组、无肿瘤性坏死组、核分裂〈25个／10HPF组及ki67≤20％、≤10％组（P〈0．05）；随访病例中，死亡、复发及转移病例（100．00％，4／4）均表达IMP3，明显高于健在且未复发、转移病例（60．00％，6／10），两组比较差异无统计学意义（P〉0．05）。在54例平滑肌瘤患者中仅5例（9．26％）弱至中度阳性表达IMP3，IMP3在平滑肌肉瘤与平滑肌瘤中的表达比较差异有统计学意义（P〈0．05）。结论：IMP3参与了平滑肌肉瘤的发生并在该肿瘤中高度表达，可作为一个新的与平滑肌瘤鉴别的辅助指标。

英文摘要：

Objective： To explore the expression and significance of insulin like growth factor- Ⅱ mRNA binding protein 3 （IMP3） in leiomyosarcoma and liomyoma. Methods： Immunohistochemical SP method was used to observe the expression of IMP3 in 15 pa- tients with leiomyosarcoma and the relationship with clinicopathological characteristics, 54 patients with liomyoma were selected as control group. Results： The positive expression rate of IMP3 in leiomyosarcoma was 73.33% （11/15） ; the positive expression rates of IMP3 in u- terine group, moderate or poor differentiation group, tumor necrosis group, mitosis count ≥25/10 HPF group, and ki67 〉20% group were statistically significantly higher than those in extrauterine group, high differentiation group, non-tumor necrosis group, mitosis count〈25/10 HPF group, and ki67≤20% group, and ki67≤10% group （P〈0. 05） ; during follow-up, all the four death, recurrent, and metastatic pa- tients （ 100.00% ） expressed IMP3, which was statistically significantly higher than that in alive patients without recurrence and metastasis （60. 00%, 6/10） （P〉0. 05 ） . Among 54 patients with liomyoma, only five patients （9. 26% ） expressed weak to moderate positive IMP3, there was statistically significant difference between leiomyosarcoma and liomyoma （P〈0. 05） . Conclusion： IMP3 plays an important role in tumorigenesis of leiomyosarcoma and the expression level of IMP3 in leiomyosarcoma is high, IMP3 can be used as a new aided index in differential diagnosis of leiomyosarcoma and liomyoma.