欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的：考察羊脂油对淫羊藿总黄酮体内药动学的影响。方法：采用药理效应法,建立小鼠肾阳虚模型,以超氧化物歧化酶为效应指标,比较淫羊藿总黄酮及其在炮制辅料羊脂油的作用下形成自组装胶束后的小鼠体内药动学参数。结果：淫羊藿总黄酮在羊脂油的作用下形成自组装胶束后,小鼠体内的药动学参数t1/2、Cmax、AUC（0-t）、AUC（0-∞）、MRT（0-∞）与淫羊藿总黄酮相比均显著增加（P〈0.05,P〈0.001,P〈0.01）。结论：炮制辅料羊脂油提高了淫羊藿总黄酮的生物利用度,促进了其体内吸收。
英文摘要：
Objective： To observe the inl uence of sheep＇s oil on pharmacokinetics of epimedium l avonoids. Methods： The mouse models with syndrome of deficiency of kidney yang were established based on the pharmacodynamics effect, and the pharmacokinetics parameters of self-assembled micelles of epimedium l avonoids with sheep＇s oil as auxiliary material were compared based on effective indicators as superoxide dismutase（SOD）. Results： After forming of self-assembled micelles of epimedium l avonoids micelles with sheep＇s oil as auxiliary material, the pharmacokinetics parameters as t1/2, Cmax, AUC（0-t）, AUC（0-∞） and MRT（0-∞） in mouse bodies were increased significantly compared with total flavonoids of epimedium（P〈0.05, P〈0.001, P〈0.01）. Conclusion： Sheep＇s oil improved the bioavailability total l avonoids of epimedium herb, and promote the absorption of total l avonoids of epimedium herb.
同期刊论文项目
同项目期刊论文
Influence of vitamin E tocopherol polyethylene glycol succinate 1000 on intestinal absorption of ica
Quality Evaluation of Yanghuo Sanqi Tablet Through a Simultaneous Determination of Five Major Active
Metabolite Profiles of Epimedin B in Rats by Ultraperformance Liquid Chromatography/Quadrupole-Time-
Preparation of a nanoscale baohuoside I-phospholipid complex and determination of its absorption: in
Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-q
Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis
期刊信息
位置：