蝴蝶霉素是一种新型的天然抗生素,由于具有特殊的抗肿瘤活性而引起人们的关注。然而,一些不利因素导致蝴蝶霉素无法直接运用于临床。为了寻找活性更好的药物先导化合物,人们对蝴蝶霉素的结构进行修饰和改造,通过生物方法和化学方法,合成了大量的类似物。本文将从化学合成角度出发,立足蝴蝶霉素及其类似物结构构造的关键步骤,对近年来的合成研究进行综述。
Rebeccamycin, a new natural antibiotics, has triggered considerable interest due to its special antitumor activity. However, it cannot be utilized directly as drugs for some disadvantages. To search for better lead compounds, the structure of rebeccamycin is modified or altered, and a variety of its analogues have been obtained via biosynthesis and chemical synthesis. Herein, we present a review about recent progress in chemical synthesis of rebeccamycin and its analogues.