报道了1种合成3,9-二氟-1,11-二脱氯-6-甲基-4′-去甲基蝴蝶霉素的新方法.采用了新的糖苷化手段,可以使吲哚并咔唑直接与未保护和活化的葡萄糖作用选择性的生成β糖苷键,省略了糖的多步保护、脱保护过程,大大简化了操作.简便的反应操作和绿色化的反应过程为合成具有强效生物活性的蝴蝶霉素类似物提供了良好的新方法.
A new approach to 3,9 - difIuoro- 1,11 - dechloro- 6 - methyl - 4 ( - demethyl rebeccamycin is reported in this paper. In this new strategy, selective glycosylation of indolecarbazole can be achieved using unprotected, unactivated glucose. The simplicity of manipulation, and environmentally benign characters makes the present method a very good way for preparation of rebeccamycin analogues.