二茂铁与乙酰氯经傅-克反应制得乙酰基二茂铁(1);1在Ru(Ⅱ)-(R,R)-TsDPEN催化下完成不对称氢转移制得手性仲醇(3);3酯化后再与二甲胺通过亲核取代反应合成了光学活性的(R)-(+)-N,N-二甲基-1-二茂铁基乙胺,总产率54.5%,其结构经1H NMR和IR确证。
Acetylferrocene(1) was prepared by Friedel-Crafts reaction of ferrocene with acetyl chloride.The asymmetric transfer hydrogenation of 1 was carried out using Ru(Ⅱ)-(R,R)-TsDPEN as the catalyst to give chiral secondary alcohol(3).(R)-(+)-N,N-dimethyl-1-ferrocenylethylamine was synthesized by the esterification of 3,then nucleophilic substitution with dimethylamine in total yield of 54.5%.The structure was confirmed by 1H NMR and IR.