中文摘要：

将以烯烃为原料通过Sharpless不对称双羟化等多步反应合成的8种手性β-氨基醇,作为有机小分子催化剂,用于催化α,β-不饱和酮的不对称环氧化反应.考察了影响对映选择性的催化剂结构、催化剂用量、氧化剂种类、溶剂、反应温度等因素.结果表明,当催化剂用量为30 mol%、氧化剂为TBHP（叔丁基过氧化氢）、正己烷溶剂、在室温下、以（1S,2R）-（＋）-1,2-二苯基-2-甲氨基乙醇（3）作催化剂时,所得环氧化物的对映体过量最高为70%ee,产率最高为84%.

英文摘要：

Starting from correspongding olefins, eight chiral β-aminoalcohols were synthesized by Sharpless asymmetric dihydroxylation and applied in the organocatalytic asymmetric epoxidation of α,β-enones. The effects of the amount of catalysts, the structure of catalysts, oxidant, solvent and reaction temperature on enantioselectivity were also studied. When the amount of catalyst was 30 mol% relative to α,β-enones, tert-butyl hydroperoxide （TBHP） as oxidant, hexane as a solvent at room temperature, （1S,2R）-1,2-diphenyl- 2-（N-methyl）aminoethanol （3） has been successfully applied as catalyst in asymmetric epoxidation of α,β-enones with the yield up to 84% and enantiomeric excesses up to 70%.