位置:成果数据库 > 期刊 > 期刊详情页
Glutamine synthetase activity and glutamate uptake in hippocampus and frontal cortex in portal hypertensive rats
  • ISSN号:1007-9327
  • 期刊名称:《世界胃肠病学杂志:英文版》
  • 时间:0
  • 分类:Q959.837[生物学—动物学] S511.01[农业科学—作物学]
  • 作者机构:[1]Institute of PharmacologicalResearch (ININFA), National Research Council of Argentina(CONICET) and University of Buenos Aires, Junin 956. 5thfloor, C 1113AAD, Buenos Aires, Argentina, [2]Laboratory of Portal Hypertension, Schoolof Pharmacy and Biochemistry, University of Buenos Aires,Junln 956.5th floor, C 1113AAD, Buenos Aires, Argentina, [3]Department ofBiological Chemistry, School of Pharmacy and Biochemistry,University of Buenos Aires, Junin 596. 5th floor, C1113AAD,Buenos Aires, Argentina
  • 相关基金:Supported by Grant B013 from the University of Buenos Aires, Argentina and PIP 5869 from National Research Council of Argentina
中文摘要:

背景:母亲的悲痛将与孩子们的心理地位相关,从而影响孩子们和母亲的自治神经系统(ANS ) 的活动。我们假设了那麻药前当近来临到他们的孩子的操作时间时,母亲的 ANS 活动将与孩子的 ANS 活动相关,并且心率可变性(HRV ) 的价值将相关。方法:我们计算了母亲并且孩子们是 HRV 并且分析在二之间的关系。24 母亲和孩子的一个总数被分析。母亲并且孩子的 HRV 在孩子的外科前从夜里被记录到到达到操作房间。结果:到孩子的高周波的部件( HF )( LF/HF 比率)和在立即的外科手术前的时期( 06:00 08:00 小时)期间获得的母亲的 HRV 的低频率的部件( LF )的比率出现了一显著地,积极关联,但是没有关联被作出对有利的裁决在外科手术前的夜里期间获得的 LF/HF 比率。结论:HRV 的 LF/HF 比率立即在在孩子和母亲的外科前显示出重要积极关联。

英文摘要:

AIM: To study glutamine synthetase (GS) activity and glutamate uptake in the hippocampus and frontal cortex (FC) from rats with prehepatic portal vein hypertension. METHODS: Male Wistar rats were divided into shamoperated group and a portal hypertension (PH) group with a regulated stricture of the portal vein. Animals were sacrificed by decapitation 14 d after portal vein stricture. GS activity was determined in the hippocampus and FC. Specific uptake of radiolabeled L-glutamate was studied using synaptosome-enriched fractions that were freshly prepared from both brain areas. RESULTS: We observed that the activity of GS increased in the hippocampus of PH rats, as compared to control animals, and decreased in the FC. A significant decrease in glutamate uptake was found in both brain areas, and was more marked in the hippocampus. The decrease in glutamate uptake might have been caused by a deficient transport function, significantly and persistent increase in this excitatory neurotransmitter activity. CONCLUSION: The presence of moderate ammonia blood levels may add to the toxicity of excitotoxic glutamate in the brain, which causes alterations in brain function. Portal vein stricture that causes portal hypertension modifies the normal function in some brain regions.

同期刊论文项目
同项目期刊论文
期刊信息
  • 《世界胃肠病学杂志:英文版》
  • 主管单位:
  • 主办单位:百世登出版集团有限公司
  • 主编:
  • 地址:太原双塔西街77号
  • 邮编:100023
  • 邮箱:
  • 电话:0351-4078656
  • 国际标准刊号:ISSN:1007-9327
  • 国内统一刊号:ISSN:
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国科学引文索引(扩展库),日本日本科学技术振兴机构数据库,瑞典开放获取期刊指南
  • 被引量:12408