中文摘要：

[目的]了解新生儿邻苯二甲酸酯（PAEs）宫内暴露的质量浓度（后称“浓度”）,并探索其与新生儿性激素或甲状腺激素水平的关联。[方法]收集新生儿胎粪并检测胎粪中常见PAEs的代谢物,收集脐带血并检测游离睾酮（FT）、总四碘甲状腺素（T4）等常见性激素指标和甲状腺激素指标,并采用线性回归方法分析两者间的关系。[结果]新生儿胎粪中检出的代谢物主要是邻苯二甲酸单乙基己酯（MEHP）、邻苯二甲酸单正丁酯（MnBP）和邻苯二甲酸单异丁酯（MiBP）,检出率分别为100%、99%和99%。男性新生儿雌二醇（E2）水平与邻苯二甲酸单甲酯（MMP）（b=2.44,P=0.027）、MnBP（b=4.08,P=0.044）及MiBP（b=3.89,P=0.003）呈正相关,FT与MEHP（b=4.42,P=0.049）呈正相关;女性新生儿性激素水平与各PAEs代谢物浓度未见关联。除男性促甲状腺激素（TSH）与邻苯二甲酸单乙酯（MEP）浓度（b=0.40,P=0.015）呈正相关外,新生儿甲状腺激素其余指标与PAEs浓度均未见关联。[结论]新生儿宫内暴露于PAEs与新生儿的性激素水平变化可能存在一定的关联。

英文摘要：

[ Objective ] To understand the fetal exposure concentrations to phthalic acid esters （PAEs） and assess the associations between PAEs concentrations and the levels of sex hormones or thyroid hormones in newborns. [ Methods ] Linear regression models were used to assess the associations between PAEs metabolites in meconium samples and sex or thyroid hormones [free testosterone （FT） and total thyroxine （T4）] in cord blood samples. [ Results ] The main metabolites in meconium were mono-2-ethylhexyl phthalate （MEHP）, mono-n-butyl phthalate （MnBP）, and monoisobutyl phthalate （MiBP）, with detection rates of 100%, 99%, and 99%, respectively. Estradiol level in newborn boys was positively correlated to the concentrations monomethyl phthalate （MMP） （b=2.44, P=0.027）, MnBP （b=4.08, P=0.044）, and MiBP （b=3.89, P=0.003）. FT in newborn boys was positively correlated to MEHP （b=4.42, P=0.049）. None of PAEs metabolite concentrations was related to sex hormone level in newborn girls. Thyroid stimulating hormone （TSH） level in newborn boys was positively correlated to MEP concentration （b=0.40, P=0.015）. No other associations between thyroid hormone levels and PAEs metabolite concentrations in meconium were found.[ Conclusion ] Fetal exposure to PAEs may be associated with changes of sex hormone levels in newborns.