中文摘要：

为达因在的单向性的运动的一个模型基于结构的观察和可得到的生物化学的试验性的结果被介绍。在这个模型，达因在的有约束力的亲密关系因为微导管(MT ) 独立于它的核苷酸状态，在强壮、弱的 MT 绑定之间的变化由在梗和 MT 之间的相对取向的变化自然地是坚定的，梗旋转跟随核苷酸状态转变。因此从腺苷 triphosphate (ATP ) 的神秘通讯在到在梗的尖端的远 MT 绑定地点的球状的域的有约束力的地点，是在传统的模型的一个前提，没被要求。用现在的模型，以前的试验性的结果象 ATP 和腺苷 diphosphate (自动数据处理)的效果那样达因在的分离上的绑定从 MT ，在浸透的领导单人赛的 axonemal 达因 ins 的运动 ATP 集中，为二头的细胞质的达因 ins 的运动的步尺寸的负担依赖和 ATP 集中上的货摊力量的依赖能是解释的井。

英文摘要：

A model for the unidirectional movement of dynein is presented based on the structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule （MT） is independent of its nucleotide state and the change between strong and weak MT-binding is determined naturally by the variation of relative orientation between the stalk and MT, as the stalk rotates following nucleotide-state transition. Thus the enigmatic communication from the adenosine triphosphate （ATP）-binding site in the globular domain to the far MT-binding site in the tip of the stalk, which is a prerequisite in conventional models, is not required. Using the present model, the previous experimental results such as the effect of ATP and adenosine diphosphate （ADP） bindings on dissociation of dynein from MT, the movement of single-headed axonemal dyneins at saturating ATP concentration, the load dependence of step-size for the movement of two-headed cytoplasmic dyneins and the dependence of stall force on ATP concentration can be well explained.