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中文摘要：
以IRGACURE2959为光引发剂,聚乙二醇双丙烯酸酯（PEGAD）和N-异丙基丙烯酰胺（NIPAM）为单体,通过紫外光引发光聚合,合成了PEGDA/NIPAM共聚物水凝胶,研究了凝胶于不同酸度介质及不同温度中对阿司匹林的释放行为。结果表明,模拟胃肠液中,随释放时间的延长,载药凝胶对药物的累积释放率增加。NIPAM单体的引入增大药物累积释放率,药物缓释时间延长,具有良好的药物释放性能。凝胶对药物的缓释受温度与释放时间的影响,在37℃和45℃时,随释放时间增加,药物累积释放率增大;在30℃时,随释放时间的增长,累积释放率先增大后减小。
英文摘要：
Copolymer hydrogels were synthesized by UV-initiated polymerization of polyethylene glycol diacrylate ester（PEGDA） and N-isopropylacrylamide（NIPAM） as monomers,with Irgacure2959 as initiator.The release behavior of aspirin from hydrogels had been studied at different temperatures and different pH mediums.The results showed that the cumulative release rate of aspirin was in correlation to increased release-time.The introduction of NIPAM monomer increased the cumulative release rate of aspirin and prolonged the time of controlled drug release and led to improvement of the performance of drug release.Both the temperature and release-time affected on the release of drugs.At 37℃ and 45℃,the cumulative release rate of aspirin increased with increasing release-time.But at 30℃,the cumulative release rate of aspirin increased at first,and then decreased.
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