中文摘要：

目的探讨虎杖苷对大鼠脑出血性损伤的治疗作用及作用机制。方法采用Ⅶ型胶原酶诱导大鼠脑出血,建立脑出血模型,观察虎杖苷对大鼠神经功能症状、脑组织中超氧化物歧化酶（SOD）活力、丙二醛（MDA）水平,脑组织Bcl-2蛋白表达,及血清中白细胞介素-1β（IL-1β）水平的影响。结果与脑出血模型组相比,虎杖苷（25、50、100 mg/kg）可显著改善脑出血后神经功能缺损,提高脑组织SOD活力、降低MDA水平,增加Bcl-2蛋白表达,降低血清中IL-1β水平,其作用与剂量呈正相关。结论虎杖苷通过对抗自由基损伤,抗凋亡及抗炎等作用,发挥对大鼠脑出血损伤的治疗作用。

英文摘要：

Objective To explore the effects and mechanisms of polydatin on rats with brain hemorrhagic injury.Methods The cerebral hemorrhage model in rats was induced by local injection of type Ⅶ collagenase and they were randomly divided into six groups.The treated groups were treated with polydatin and Naoxuekang;The normal and control groups were only treated with water.The changes of neurological defect were observed.The activity of SOD,the content of MDA,the protein expressions of Bcl-2 in brain tissue,and the contents of IL-1β in serum were measured.Results Compared with the cerebral hemorrhage model group,polydatin（25,50,and 100 mg/kg） could significantly reduce the symptoms of neurological deficits of cerebral hemorrhage rats,raise the activity of SOD,reduce the content of MDA,increase the protein expressions of Bcl-2,and decrease the contents of IL-1β in serum.Its effects were positively correlated with the dose-effect.Conclusion Polydatin has therapeutic effect on rats of cerebral hemorrhage,through against free radical damage and inhibiting neuronal apoptosis and inflammatory.