The global exponentially stability was studied for time-delay and time-varying measure large scale systems with impulsive effects. Firstly, the concepts are drawn for the functional category. Secondly, some sufficient conditions of the uniformly stability and the global exponentially stability are given for the above systems through defining a Lyapunov function of the weighting sum of the variable absolute by using the Lyapunov function method and the comparison principle. At the same time, the new conclusion of stability of these systems is more universal and contains the existing results. Finally, an example is given to illustrate the feasibility and validity of the obtained results.