中文摘要：

目的描述高血压患者中同型半胱氨酸血症和高同型半胱氨酸血症的流行特征与影响因素。方法在深圳市南山区社区中,采用分层抽样方法抽选居住满6个月以上、20岁以上的原发性高血压患者5935名,主要通过问卷调查、体格测量和实验室检测来收集相关资料。采用χ^2检验分析一般特征资料和logistic回归分析高同型半胱氨酸血症的影响因素。结果①研究人群高同型半胱氨酸（Homocysteine,Hcy）均值为13.60μmol/L,其中男性15.96μmol/L、女性11.70μmol/L,男性明显高于女性（P〈0.01）;高Hcy血症（Hcy≥15μmol/L）患病率为31.39%,其中男性为46.45%,女性为16.73%。根据年龄分组（〈50岁、50-60岁、60-70岁、≥70岁）,Hcy分别为（13.20±1.62）μmol/L、（12.55±1.49）μmol/L、（13.46±1.43）μmol/L、（15.64±1.49）μmol/L,4组之间的差异均具有统计学意义（P〈0.000 1）;高Hcy血症患病率分别为26.82%、23.95%、29.47%、48.15%,差异具有统计学意义（P〈0.000 1）。②logistic回归分析结果显示,高血压患者中年龄、吸烟、高盐饮食、收缩压、尿酸、肌酐、水果摄入量引发高Hcy血症的OR（95%CI）分别为1.45（1.36-1.54）、1.24（1.05-1.47）、1.13（1.00-1.27）、1.11（1.03-1.2）、1.32（1.07-1.50）、和3.94（3.19-4.61）和0.75（0.66-0.87）。结论高血压患者血浆Hcy及高Hcy血症均呈现男性多于女性、随年龄增长而升高的特征。高血压患者中年龄、吸烟、高盐饮食、收缩压、尿酸和肌酐是高Hcy血症的危险因素,而水果摄入量是高Hcy血症的保护因素。

英文摘要：

Objective To describe characteristics of prevalence of hyperhomocysteinemia and risk factors in hypertensive patients. Methods A number of 5935 hypertensive patients who are over 20 years old and lived over 6 months from 60 communities in Shenzhen Nanshan district were assured by stratified sampling method, and they were conducted a questionnaire survey, physical measurements and laboratory testing. We used chi -square test to analyze general characteristics and used logistic regression to analyze association factors of hyperhomocysteinemia. Results 1 ）The mean of hemocysteine （Hcy） in hypertensive patients was 13.60 μmol/l; Hcy in male was 15.96 μmol/l, in female was 11.70 μmol/l, Hcy in male was significantly higher than in female （P 〈0.01 ）.The prevalence of hyperhomocysteinemia was 31.39%, 46.45% in males and 16.73% in females. According to the age group （ 〈50 years old,50 -60 years old,60 -70 years old, 〉170 years old） , Hcy were （13.20 ±1. 62） μmol/l, （12.55 ±1.49） μmol/l, （13.46 ±1.43）μmot/l and （15.64±1.49） μmoL/l, respectively. The levels of Hey in four age groups were significantly different. The prevalence of hyperhomocysteinemia were 26.82% ,23.95 % ,29.47 % and 48.15 % , respectively, significantly higher in 〉170 years old group. 2）The resuits of logistic regression showed that age, smoking, high - salt diet, systolic pressure, uric acid, creatinine and fruit intake were influencing factors, the odds ratios （ORs） and 95% CIs for hyperhomocysteinemia were 1.45 （1.36±1.54）, 1.24 （1.05-1.47）, 1.13 （1.01-1.27）, 1.11 （1.03-1.20）, 1.32 （1.07-1.50）, 3. 94 （3.19 - 4.61 ）, 0.75 （0.66 - 0.87 ）, respectively. Conclusion Hcy levels and hyperhomocysteinemia prevalence increased with age and male is significantly higher than female. Age, smoking, high - salt diet, systolic pressure, uric acid and creatinine are the risk factors of hyperhomocysteinemia, while fruit intake is a protective factor.