中文摘要：

目的：制备壳聚糖作载体的结肠靶向给药制剂，并评价其体外释药性能。方法：将亚甲蓝与壳聚糖形成小丸，再以丙烯酸树脂（Ⅱ）包裹该小丸，以分光光度法测定其体外释放性能。结果：该小丸在pH1．2盐酸溶液及pH6．8磷酸缓冲液中药物累积释放量8h内小于6％，而在人工结肠液中，14h时累积释放度为38％左右。结论：用丙烯酸树脂（Ⅱ）包膜的壳聚糖制剂具有潜在的结肠靶向释药效果。

英文摘要：

Objective： To prepare colon-specific delivery system using chitosan as carrier and to evaluate the release of this dosage form in vitro. Method： Chitosan pillets containing methylene blue were obtained in NaOH/ethanol and the pillets then were coated with acrylic resin （ Ⅱ ）. The in vitro release of the pillets was determined by the spectrophotometric method. Results： The accumulated release of methylene blue in the pillets was less than 6% within 8 h in the artificial medium of the stomach and small intestine, while the release reached about 38% in the case of the large intestinal liquid in 14 h. Conclusion： Acrylic resin （Ⅱ） coated chitosan pillets had the potential to release the drug in colon.