中文摘要：

目的：探讨纤支镜肺泡灌洗及局部注射药物对镍接触者下呼吸道感染的疗效。方法：选取2012年1月至2016年10月金昌市中心医院呼吸科收治的接触镍5年以上合并有下呼吸道感染出现较多脓痰患者40例,随机分为对照组和观察组,每组20人,对照组给予静滴抗菌药物、化痰药物及雾化糜蛋白酶治疗,观察组在上述治疗基础上联用经纤支镜肺泡灌洗及注射药物治疗,比较两组PaO2、PaCO2、hs-CRP、ESR、平均住院天数、死亡率上变化及临床疗效转归。结果：观察组和对照组PaCO2、hs-CRP、ESR较治疗前均有下降（P〈0.01）,观察组及对照组PaO2均有升高,观察组与对照组比较,差异有统计学意义（P〈0.01）。观察组总有效率高于对照组（χ2=4.29,P〈0.05）,观察组平均住院天数（10.7±5.4）天低于对照组（14.6±4.3）天,观察组死亡率（5%）低于对照组（15%）。结论：经纤支镜肺泡灌洗及注射药物治疗镍接触者下呼吸道感染效果肯定,具有临床应用价值。

英文摘要：

Objective：To explore the clinical effect of beonchoalveolar lavage and local injection in nickel exposed workers with lower respiratory infection. Methods：40 nickel exposed workers with lower respiratory infection from Jinchang Central Hospital from January 2012 to October 2016 were randomly divided into the trial group and the control group,with 20 workers in each group, intravenous antibiotics, phlegm drugs and atomization chymotrypsin were given to patients in both groups, while bronchoalveolar lavage and local injection were applied to patients in trial group. PaO2, PaCO2, hs-CRP, ESR, clinical outcomes, days of hospitalization and mortality were observed. Results：PaO2, PaCO2, hs-CRP, ESR, symptom, sign, chest imaging data of the patients in two groups were significantly improved（P〈0.05 ）and the improvement in the tri- al group was much superior to that in control group with obvious statistic difference（P〈0.01 ）. The average hospitalized day and mortality were shorter in the trial group than that in control（P〈0.05 ）.Conclusion： The treatment of bronchoalveolar lavage and local injection were effective to nickel exposed workers with lower respiratory infection.