中文摘要：

目的：观察运动疲劳后大鼠苍白球内侧部（GPi）和黒质网状部（SNr）神经元自发放电的变化,探讨GPi和SNr在运动疲劳中枢调控中的作用机制。方法：采用玻璃微电极胞外记录技术,在体观察运动疲劳后大鼠GPi和SNr神经元自发放电活动的变化并对放电频率和放电形式进行统计分析。结果：运动疲劳后大鼠GPi神经元自发放电频率较对照组显著升高,不规则放电神经元比例显著增多,平均峰峰间隔显著小于对照组;运动疲劳大鼠SNr神经元自发放电频率较对照组显著升高,不规则放电和爆发式放电神经元比例显著增多,平均峰峰间隔和变异系数均显著小于对照组。结论：运动疲劳大鼠GPi和SNr神经元电活动出现明显改变,主要表现为兴奋性增强但二者放电形式的变化有差异。运动疲劳状态下,间接通路比直接通路更活跃,使GPi、SNr神经元兴奋性增强,最终使运动皮层受到抑制。

英文摘要：

Objective ： In order to reveal the role of GPi/SNr in the central mechanism of exercise-induced fatigue, this research investigates the spontaneous firing of GPi and SNr neurons in rats. Methods： Use the extracellular glass microelectrode technique to observe the changes of spontaneous firing of GPi and SNr neurons in rats in vivo after exercise-induced fatigue, and analyze the frequencies and patterns of spontaneous firing. Results： The spon- taneous firing frequencies of GPi and SNr neurons in the fatigue group are significantly higher compared with the control group. There appears irregular discharge in both GPi and SNr neurons, and there is remarkable increase of bursting discharge in SNr. The mean ISI and CV of SNr in the fatigue group are significantly greater than the con- trol group, but only the mean ISI of GPi in the fatigue group are significantly greater than the control group. Con- clusion： Neurons activities of GPi and SNr change significantly in rats after exercise-induced fatigue, which are characterized by the decrease in excitability but different changes in regularity of activity, The indirect pathway is more active than the direct pathway during exercise-induced fatigue, and thereby GPi and SNr are excited, which finally give rise to suppression of motor cortex.