自噬是将细胞质组分运输至溶酶体的细胞内降解系统,参与物质及能量的循环,同时自噬作为一种细胞死亡方式被称为Ⅱ型程序性死亡。近年来研究表明自噬参与神经系统疾病尤其是神经退行性疾病、缺血缺氧、脑外伤、惊厥等疾病的病理生理过程。
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome and it's involved Jn the cycle of matter and energy, Meanwhile autnphagic cell death is a form of cell death called type-Ⅱ programmed cell death. In recent years, studies have shown that autophagy is involved in pathophysiologies of nervous system disease especially neurodegenerative diseases, ischemia-hypoxia, traumatic brain injury, seizures.