中文摘要：

人类染色体蛋白质组计划（Chromosome-Centric Human Proteome Project,C-HPP）是由人类蛋白质组组织（Human Proteome Organization,HUPO）于2010年9月在悉尼召开的第九届国际蛋白质组学大会上正式提出的大型国际合作计划。与生理-病理驱动的人类蛋白质组计划（Biology/Disease-driven HPP,B/D-HPP）相同,C-HPP是人类蛋白质组计划（Human Proteome Project,HPP）的主要工作,将由中国、美国、澳大利亚、瑞士、意大利等17个国家的25个研究团队共同合作,旨在10年内（2012.09—2022.09）完成人类24条染色体和线粒体上蛋白质编码基因产物本身及其修饰产物的检测、验证和确认,注销可能过度注释的编码基因,绘制基因图谱并实现人类基因组的重注释。国内军事医学科学院的贺福初院士和徐平教授、复旦大学的杨芃原教授、华大基因的刘斯奇教授和暨南大学的何庆瑜教授,以及台湾地区的陈玉如教授分别领衔承担了人类第1号、8号、20号和第4号染色体上蛋白质编码基因的研究任务。综述了我国承担的C-HPP工作的策略和进展,并提出展望。

英文摘要：

The Chromosome-Centric Human Proteome Project （C-HPP） is a major international cooperation project proposed by the Human Proteome Organization （HUPO） at the 9th international conference on proteomics held in Sydney, Australia in September, 2010. Similar to the Biology/Disease-driven Human Proteome Project （B/D-HPP）, C-HPP is one component of Human Proteome Project （HPP）. Twenty-five research teams from 17 countries including China, America, Australia, Switzerland, Italy, etc, are cooperating to complete the three goals of C-HPP, which are （1） to detect, verify, and validate the protein-coding gene products as well as their single amino acid variants （SAAVs）, post-translational modifications （PTMs） and other possible variants on the 24 human chromosomes and mitochondrial DNA; （2） withdraw the over-annotated coding genes; （3） achieve gene mapping and address reannotation of the human genome within 10 years （2012/9-2022/9）. HE Fu-Chu and XU Ping from Academy of Military Medical Sciences, YANG Peng-Yuan from Fudan University, L1U Si-Qi from BGI and HE Qing-Yu from Jinan University, and CHEN Yu-Ru from Academia Sinica will respectively lead the work to research the protein-coding genes of human chromosome l, 8, 20 and 4. This paper reviews the strategies and progress of the work Chinese teams undertook in C-HPP, and proposes prospects for our work.