目的:研究三角叶凤毛菊Saussurea deltoidea(DC.)Schulz-Bip.中具有抗肿瘤活性的三萜类化学成分。方法:利用正/反相硅胶柱色谱色谱、凝胶分子筛色谱、HPLC等色谱学方法分离、纯化化合物,运用波谱学方法鉴定化合物结构。结果:从三角叶凤毛菊乙酸乙酯萃取部位分离鉴定出7个三萜类化合物,其结构分别为:taraxast-20-ene-3β,3-O-diol(1),3β-hydroxy-11-oxo-ursan-12-ene(2),3β-hydroxy-taraxast-20-ene-30-aldehyde(3),21α-hydroxy-taraxasterol(4),ursan-9(11),12-diene-3β-ol(5),ursan-9(11),12-diene-3β-O-acetate(6),3β-hydroxy-9(11),12-diene-oleanol(7)。结论:7个三萜类化合物都是首次从该植物中分离得到。
Objective: Investigate the triperpenoids of Saussurea deltoidea with antitumor activities.Method: Use various chromatography methods such as silica gel,RP-18 silica gel,Sephadex LH-20 column chromatography,HPLC,et al.Result: Seven compounds were isolated from the title plant.Their structures were elucidated by spectral analysis.7 triperpenoids were isolated and elucidated as taraxast-20-ene-3β,30-diol(1),3β-hydroxy-11-oxo-ursan-12-ene(2),3β-hydroxy-taraxast-20-ene-30-aldehyde(3),21α-hydroxy-taraxasterol(4),ursan-9(11),12-diene-3β-ol(5),ursan-9(11),12-diene-3β-O-acetate(6),3β-hydroxy-9(11),12-diene-oleanol(7).Conclusion: All the compounds were isolated from S.deltoidea for the first time.