中文摘要：

目的：通过对广西112例地中海贫血病例的回顾性分析，了解地中海贫血患者的临床特点、治疗现状和并发症。方法用回顾性分析方法对广西112例地中海贫血患者（α中间型16例，β中间型30例，β重型66例）的临床特点、治疗现状和并发症进行分析。结果（1）52例β重型地贫患者和所有需长时间频繁输血的中间型地贫患者输血前H b＜90 g/L。（2）不规范祛铁治疗的β中间型和β重型患者分别为84.0％和89.8％。（3）112例患者中，74例（67.9％）存在铁过载，2例α中间型，19例β中间型，53例β重型。（4）2例β中间型和1例β重型患者曾发生心力衰竭；2例β重型患者有继发性糖尿病；17例β中间型和46例β重型患者身材矮小，身材矮小与铁蛋白、输血前血红蛋白量相关（ r＝0.336，P＜0.001；r＝-0.243，P＝0.011）。结论本组β中间型地贫和β重型地贫患者输血和去铁治疗不规范，铁过载严重，身材矮小、心力衰竭等并发症发生率高。

英文摘要：

Objective Through the retrospective analysis of 112 cases of thalassemia in Guangxi province ,explore the clinical features ,treatment status quo and complication in patients with thalassemia . Methods Analysis of the clinical characteristics ,treatment and complication of 112 thalassemia patients（16α-thalassemia intermediate ,30β-thalassemia intermediate ,66β-thalassemia major） in Guangxi with a retrospective analyzed method . Results （1）52β-thalassemia major patients and all long time frequent blood transfusions patients of β-thalassemia interme-dia with pre-transfusion Hb〈90 g/L .（2）Iron chelation therapy was used irregularly in 84% patients of β-thalasse-mia intermediate and 89.8% patients of β-thalassemia major .（3）In 112 thalassemia patients ,74 patients （67.9% ） with iron overload ,including two α-thalassemia intermediate patients ,19 β-thalassemia intermediate patients ,53 β-thalassemia major patients .（4）Two β-thalassemia intermediate patients and one β-thalassemia major patient with severe heart failure ;two β-thalassemia major patients with secondary diabetes mellitus ;17β-thalassemia intermedi-ate patients and 46β-thalassemia major patients with severe short stature ,short stature was correlated with levels of ferritin and pre-transfusion Hb （r=0.336 ,P〈0.001 ;r= -0.243 ,P=0.011） . Conclusion Our data showed that ,blood transfusion and iron chelation therapy were not standardized in the β-thalassemia intermedia and β-thalassemia major patients ,iron overload severely ,a high incidence of complications such as heart failure ,diabetes mellitus and short stature .