中文摘要：

脑肿瘤中恶性肿瘤较为常见,脑瘤发展快、治疗难导致了较高的死亡率。采用化学药物治疗时,药物进入脑肿瘤组织必须通过血脑屏障和血-脑瘤屏障。一些有潜力的抗肿瘤药物由于自身物理化学性质的限制,不能有效到达肿瘤。针对脑肿瘤形成和发展不同阶段的特点,目前脑肿瘤靶向递药有3种策略：跨血脑屏障（BBB）转运递药、跨血-脑瘤屏障（BBTB）转运递药和利用实体瘤的高通透性和滞留效应（EPR效应）递药,已被广泛研究的纳米递药载体有脂质体、固体脂质纳米粒、聚合物胶束、树枝状聚合物、碳纳米管、聚合物纳米粒、磁性纳米粒等。控制载药纳米微粒粒径大小以及对其表面进行修饰可改善药物在体内的分布与滞留,提高化疗药物的疗效,降低毒副作用。多级靶向纳米递药系统有潜力成为治疗脑肿瘤的重要辅助方式。

英文摘要：

Malignant tumor is prevalent in brain tumors. Fast growth, difficulty in treatment and poor prognosis resulted in a terrible mortality. When chemotherapeutics penetrate from blood vessels into tumor tissues, there are two obstacles in brain tumor treatment： blood-brain barrier（BBB） and blood-brain tumor barrier（BBTB）. Some anti-tumor drugs can not effectively reach into the brain tumor due to the limitation of the physical and chemical properties of these drugs. The targeting strategies are introduced aimed at differentstages of brain tumor development and growth. There are three strategies for brain tumor-targeted nanovehicle drug delivery： drug delivery across blood-brain barrier（BBB）, blood-brain tumor barrier（BBTB） and enhanced permeability and retention effect（EPR）. Many Nanocarriers for drugs were studied such as lipidosome, solid lipid nanoparticles, polymeric micelles, dendrimer, carbon nanotube, polymeric nanoparticles, magnetic nanoparticles and so on. Nanocarriers would localize the therapeutic drugs and enhance retention time at the brain tumor, meanwhile minimize the involvement of peripheral tissues and healthy brain tissue to reduce side effects by controlled particle size and surface modification. Whole-process targeted nano-drug delivery systems according to characteristics of brain tumor growth are expected to be a potential trend for brain cancer treatment.