中文摘要：

目的探讨炎症相关因子IFN-α、TGF-β1与颅咽管瘤炎症反应的关系。方法采用免疫组化GTvision^TM 法检测α-干扰素（interferon-α，IFN-α）、转化生长因子-β1（transforminggrowthfactorβ1，TGF-β）在58例颅咽管瘤组织中的表达情况，比较不同病理类型颅咽管瘤、复发组及初发组颅咽管瘤组织中IFN-α、TGF-β1的表达水平。结果造釉细胞型及复发颅咽管瘤IFN-α表达广泛。44例造釉细胞型颅咽管瘤有40例IFN-α仪表达阳性（90．91％），鳞状乳头型14例中有12例表达阳性，造釉细胞型IFN-α阳性表达率明显高于鳞状乳头型（Z=-2．003，P〈0．05）。16例复发颅咽管瘤均有IFN-α阳性表达，阳性表达率高于初发组（Z=-2．085，P〈0．05）。TGF-β1在鳞状乳头型颅咽管瘤明显表达，14例中有10例阳性表达，而造釉细胞型44例仅有14例表达阳性（Z=-2．129，P〈0．05）。经Spearman相关分析，在全部颅咽管瘤中，IFN-α与TGF-β1表达程度呈负相关（rs=-0．273，P〈0．05）。结论颅咽管瘤存在复杂的炎症反应，炎症相关因子IFN-α、TGF-β1可能参与颅咽管瘤细胞的生长调控，两者之间可能存在拮抗作用。

英文摘要：

Objective To investigate the expression of pro-inlfammatory factors Interferon-alpha （IFn-α ） and transforming growth factor β1 （TGF-β1） in tumor-assoeiated inflammation in patients with craniopharyngioma. Methods GTVisionTM immunohistochemistry was used to detect the expression of IFn-α and TGF-β1 in 58 specimens of craniopharyngiomas. Results IFn-α was positive in 40 of 44 cases of admantinomatous craniopharyngiomas and in 12 of 14 cases of squamous-papillary craniopharyngiomas. IFN-α -positive rate was higher in admantinomatous craniopharyngiomas than in squamous-papillary craniopharyngiomas （Z = -2.003, P 〈 0.05）. IFn-α was positive in all 16 recurrent eraniopharyngioma. IFn-α positive rate was significantly higher in recurrent craniopharyngiomas than in primary craniopharyngiomas （Z = -2.085, P 〈 0.05）. TGF-β1 was positive in 10 of 14 cases of squamous- papillary craniopharyngiomas and in 14 of 44 cases of ameloblastomatous eraniopharyngiomas. The positive rate of TGF-β1 was significantly higher in squamous-papillary craniopharyngiomas than in ameloblastomatous craniopharyngiomas （Z = -2.129, P 〈 0.05）. Spearman correlation analysis revealed a negative correlation between IFN-α and TGF-β1 expression in all craniopharyngioma （rs = -0.273, P 〈 0.05）. Conclusion The inflammation process is very complex in craniopharyngiomas in which IFn-α and TGF-β1 might antagonistically regulate the growth of craniopharyngiomas.