中文摘要：

目的：研究双参通冠方对急性心肌梗死模型大鼠血流动力学的影响。方法：SD大鼠分为假手术组、模型组及双参通冠低（2．5g/kg）、中（5g／kg）、高（7．5g/kg）剂量组，结扎冠状动脉左前降支建立大鼠心肌梗死模型，于十二指肠给药后0、15、30、60、90、120、180min，采用PowerLab血流动力学信号采集与分析系统，分别检测大鼠的HR、MAP、LVSP、LVEDP、LVdp／dtmax、LVdp／dtmin c。结果：与假手术组比较，模型组各时间点HR、MAP均升高，LVSP、LVEDP、LVdp／dtmax、LVdp／dtmin降低（P〈0．05）。与模型组比较双参组用药15rain后HR、MAP均降低，LVSP、LV—EDP、LVdp／dtmax、LVdp／dtmin均显著升高（P〈0．05）。双参通冠高剂量组LVSP、LVEDP、LVdp／dtmax、LVdp／dtmax改变与中低剂量组有显著差异（P〈0．05）。结论：双参通冠方能增加急性心梗模型大鼠心脏搏出量、降低心肌耗氧量和血管外周阻力，从而改善心功能。

英文摘要：

Objective：To research the effects of Shuang Shen Tong Guan Decoction（SSTGD） on hemodynamics in rats with acute myocardial infarction（AMI）. Methods：SD rats were divided into sham operation group, model group, SSTGD low-dose group （2. 5 g/ kg） ,SSTGD middle-dose group （5 g/kg） and SSTGD high-dose group （7. 5 g/kg）. The levels of HR, MAP, LVSP, LVEDP, LVdp/ dtmax and LVdp/dtml. were detected by PowerLab at 0, 15,30,60,90,120,180 min after administration. Results：Compared with the sham operated group, the levels of HR, MAP were increased, the levels of LVSP, LVEDP, LVdp/dtmax and LVdp/dtmin were reduced at each detected point in model group, the difference was significant （ P 〈 0. 05 ）. Compared with the model group, HR and MAP were decreased in SSTGD low-dose group, SSTGD middle-dose group and SSTGD high-dose group after 15 min;LVSP, LVEDP, LVdp/dtm= and LVdp/dtmin were higher,there was significantly difference（P 〈 0.05 ）. Compared with SSTGD low-dose group and SSTGD middle- dose group, the difference of LVSP, LVEDP, LVdp/dtmax and LVdp/dtmin was statistically significant in SSTGD high-dose group （ P 〈 0. 05 ）. Conclusiou：SSTGD can improve cardiac function by increasing heart stroke volume, decreasing cardiac oxygen consumption and total peripheral vascular resistance.