欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
高选择性的有机合成反应已进行了大量的研究，但是对于不同异构体的合成往往需要不同的合成途径进行，通过简单的方法如催化剂结构的微调、反应条件、添加剂等实现选择性调控迄今为止仍然具有相当的挑战性。本项目拟通过化学键活化、断裂和选择性构建本质的认识，设计新型的催化剂(试剂)，改变反应的环境条件或微调催化剂结构，在控制反应选择性的基础上发展选择性调控的新方法和新策略，加深对反应选择性控制本质和规律的认识和理解。
英文摘要：
stereoselectivity；sidearm strategy；chiral ligand；chiral carbene catalysts；catalytic asymmetric reaction
结论摘要：
本项目主要针对有机反应的选择性调控开展研究，发展选择性控制的新方法和新策略，探索和认识有机反应中选择性控制的本质和规律。工作针对金属配合物和有机小分子两大催化体系，主要利用“边臂策略”设计催化剂，辅以配体结构调节等手段，实现有机反应的选择性控制。研究结果包括发展了一系列边臂修饰的手性三噁唑啉和双噁唑啉配体，通过调节边臂的性质，实现了金属配合物催化环丙烷不对称开环/环化，多取代烯烃不对称环丙烷化，以及不对称Nazarov、Cannizzaro、Kinugasa等反应的对映选择性控制，为合成具有重要生理活性的多种手性分子提供了有效方法；通过配体结构调节，在羰基叶立德的化学选择性环化反应中实现了七元环苯啅类衍生物和二氢呋喃化产物之间的选择性调控。利用手性卡宾催化剂取代基与边臂羟基导向基团协同作用等，发展卡宾等有机小分子催化烯酮、醛、联烯环化反应的选择性调控，包括非对映选择性、对映选择性及不同反应类型的调控；快速高选择性得到多种四元、五元、六元杂环化合物。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Enantioselective synthesis of 2,5-dihydrobenzo [b] azepine derivatives via iridium-catalyzed asymmet
Unusual Formal [4 + 2] Cycloaddition of Ethyl Allenoate with Arylidenoxindoles: Synthesis of Dihydro
Phosphine-catalyzed [3 + 2] cycloaddition of allenoates with trifluoromethylketones: Synthesis of di
Diastereoselective Synthesis of 4-Hydroxytetralones via a Cascade Stetter-Aldol Reaction Catalyzed b
Highly Enantioselective Synthesis of Tetrahydrocarbolines via Iridium-Catalyzed Intramolecular Fried
PPh3-mediated intramolecular conjugation of alkyl halides with electron-deficient olefins: facile sy
NHC-Catalyzed Enantioselective [2 + 2] and [2 + 2 + 2] Cycloadditions of Keteneswith Isothiocyanates
Metal-free Synthesis of Polysubstituted Pyrroles by (Diacetoxyiodo)benzene-Mediated Cascade Reaction
Highly Enantioselective [3+2] Annulation of Cyclic Enol Silyl Ethers with DonorAcceptor Cyclopropane
Enantioselective Synthesis of Tetrahydroisoquinolines via Iridium-Catalyzed Intramolecular Friedel-C
Iridium-Catalyzed Asymmetric Allylic Etherification and Ring-Closing Metathesis Reaction for Enantio
Asymmetric N-Allylation of Indoles Through the Iridium-Catalyzed Allylic Alkylation/Oxidation of Ind
Tris(oxazoline)/copper-catalyzed coupling of alkynes with nitrones: a highly enantioselective access
Phosphane-Catalyzed [4+2] Annulation of Allenoates with Ketimines: Synthesis of Sultam-Fused Tetrahy
Reactions of Iron Carbenes with ,-Unsaturated Esters by Using an Umpolung Approach: Mechanism and Ap
Highly Enantioselective Synthesis of Multifunctionalized Dihydrofurans by Copper-Catalyzed Asymmetri
Ylide Hydrolysis in Tandem Reactions: A Highly Z/E-Selective Access to 3-Alkylidene Dihydrobenzofura
Reaction of trisubstituted alkenes with iron porphyrin carbenes: facile synthesis of tetrasubstitute
Palladium-Catalyzed Regio- and Enantio-selective Allylic Substitution Reaction of Monosubstituted Al
Enantioselective synthesis of 2,3-dihydro-1H-benzo [b]azepines: Iridium-catalyzed tandem allylic vin
DABCO-catalyzed [2+2] cycloaddition reactions of allenoates and trifluoromethylketones: synthesis of
N-heterocyclic carbene-catalyzed [4 + 2] cycloaddition of ketenes and 3-aroylcoumarins: Highly enant
N-heterocyclic carbene catalysis: Enantioselective formal [2+2] cycloaddition of ketenes and N-sulfi
Enantioslective Synthesis of Spirocyclic Oxindole-?-lactones via N-heterocyclic carbene-Catalyzed Cy
Diastereoselective Synthesis of 6-Trifluoromethyl-5,6-dihydropyrans via Phosphine-Catalyzed [4+2] An
Diversity oriented synthesis of indole-based peri-annulated compounds via allylic alkylation reactio
Catalytic Asymmetric Intramolecular Cascade Reaction for the Construction of Functionalized Benzobic
Highly Selective Ylide-Initiated Michael Addition/Cyclization Reaction for Synthesis of Cyclohexadie
Highly diastereoselective construction of fused carbocycles from cyclopropane-1,1-dicarboxylates and
A chiral cagelike copper(I) catalyst for the highly enantioselective synthesis of 1,1-cyclopropane d
Iridium-Catalyzed Enantioselective Allylic Alkylation of Methyl 2-(4-nitrophenylsulfonyl)acetate and
Palladium(0)-Catalyzed Dearomative Arylation of Indoles: Convenient Access to Spiroindolenine Deriva
Pyrrolidine-ureas as bifunctional organocatalysts for asymmetric Michael addition of ketone to nitro
A Tandem Intramolecular Michael Addition/Wittig Reaction for the Synthesis of Fused Cyclohexadiene D
Switch of addition and ring-opening reactions of oxabicyclic alkenes with terminal alkynes by sp2-C,
Enantioselective Formal [2+2] Cycloaddition of Ketenes with Nitroso Compounds Catalyzed by N-heteroc
Enantioselective Synthesis of Indole-Fused Dihydropyranones via Catalytic Cycloaddition of Ketenes a
Formal [3+2] Cycloaddition of Ketenes and Oxaziridines Catalyzed by Chiral Lewis Bases: Enantioselec
Iridium-Catalyzed Allylic Vinylation and Asymmetric Allylic Amination Reactions with ortho-Aminostyr
Enantioselective [2+2+2] cycloaddition of ketenes and carbon disulfide catalyzed by N-heterocyclic c
Stereoselective synthesis of 1-aminocyclopropanecarboxylic acid derivatives via ylide cyclopropanati
相关项目
唐勇的项目