欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
本研究旨在阐明代谢综合征及其血管病变的病生理机制。本研究群体以北京大学医学部教育部分子心血管学重点实验室和生理与病生理学系为依托，由8个研究代谢性血管病变的课题组，在长期共同培养研究生，合作申请基金，具体项目协作、共享技术平台，而自然形成的一个具有共同研究方向的科研团队。团队研究骨干的研究背景各异，但优势互补；人员年龄不同，但新老结合；各人在本学科都有很好的积累，合作使机能和生化研究结合，基础和临床研究结合。近五年已在Circ Res 和 JBC等国际SCI杂志发表原著论文200余篇，每年平均IF逐步提高，在国际同行中正在逐渐崭露头角，已于2004年获得教育部首批 "创新团队"称号。拟研究的方向有1.代谢性核受体与代谢性血管病变发病的分子机制；2.血管活性分子对血管损伤的保护作用；3.代谢性血管病变的实验治疗研究。以期在较短时间内形成一支在该领域有国际影响力的研究群体。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Stimulation of Adenosine A2B Receptors Induces Interleukin-6 Secretion in Cardiac Fibroblasts via PK
Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose
Activation of peroxisome proliferator-activated receptor γ downregulates soluble epoxide hydrolase i
(-Adrenoceptor agonists for the treatment of vasovagal syncope: a meta-analysis of world wide publis
Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovas
Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myo
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endoth
DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1 depe
Mechanisms underlying different responses of plasma triglyceride to high-fat diets in hamsters and m
Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycar
Cartilage oligomeric matrix protein maintains the contractile phenoty of vascular smooth muscle cell
Rosiglitazone Attenuates Endothelin-1-Induced Vasoconstriction by Upregulating Endothelial Expressio
Presynaptic Defects underlying Impaired Learning and Memory Function in Lipoprotein Lipase Deficient
AMP-activated protein kinase potentiates hypertonicity-induced apoptosis by blocking the NF-κB/COX-2
PGC-1α attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in th
MicroRNA Set: a novel way to uncover the potential black box of chronic heart failure in microRNA mi
Regulation of gap-junction protein connexin 43 by beta-adrenergic receptor stimulation in rat cardio
Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essent
Mitochondrial O2.-promoting p65 nuclear translocation mediates high-phosphate-induced vascular calci
Fenoterol, a beta(2)-adrenoceptor agonist, inhibits LPS-induced membrane-bound CD14, TLR4/CD14 compl
Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by me
HDL of Patients with Type 2 Diabetes Mellitus Elevates the Capability of Promoting Migration and Inv
Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydr
Reduced HDL2b in non-obese type 2 diabetic patients analyzed by a microfluidic chip method in a case
ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-injured R
Distinct AMPK phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angi
Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting wit
14-3-3 inhibits insulin-like growth factor-I-induced proliferation of cardiac fibroblasts via a phos
Effects of Onion Extract on Endogenous Vascular Hydrogen Sulfide and Adrenomedulin in Atheroscleroti
相关项目
王宪的项目