欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
本研究通过野外调查、现场大型原位实验及室内毒理学实验等相结合的方式，围绕微囊藻毒素（MC）在湖泊生态系统食物网中的迁移转化规律、不同动物类群对MC的毒理学响应以及MC对水产品食用安全性的影响等方向进行了深入的研究，发现虽然MC沿食物链无明显的生物放大作用，但处于食物链顶端的鱼类受MC的影响更大，可能源于解毒能力的差异；通过体内实验发现MC对家兔线粒体的超微结构、呼吸链酶复合物和ATPase有显著影响，肝线粒体损伤明显比心肌严重。室内MC暴露延迟南方大口鲇卵的发育（延迟2-10小时），阻碍幼体生长，降低了孵化率（达45%），导致高畸形率（达15%）以及一系列肝细胞损伤症状。巢湖专业渔民的日摄食率为2.2-3.9 ug MC-LReq，长期的MC暴露导致了渔民一定程度的肝损伤。首次建立了用LC/MS同时测定鱼类肝脏和肾脏中MC-LR和MC-LR-GSH的方法，MC-LR的加标回收率为91-103%，MC-LR-GSH的加标回收率为65.0—75.7%，在MC的毒理学研究具有重要意义。本研究共发表SCI论文32篇，出版专著2部。
结论摘要：
英文主题词microcystin, food chain, fisheries products, toxicological effects, liver damage
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Microcystin accumulation in freshwater bivalves from Lake Taihu, China, and the potential risk to hu
Bioaccumulation of the hepatotoxic microcystins in various organs of a freshwater snail from a subtr
In situ studies on physiological and biochemical responses of four fishes with different trophic lev
Hematological and plasma biochemical responses of crucian carp (Carassius auratus) to intraperitonea
Biochemical and ultrastructural changes of the liver and kidney of the phytoplanktivorous silver car
In situ study on the control of toxic Microcystis blooms using phytoplanktivorous fish in the subtro
In situ studies on the bioaccumulation of microcystins in the phytoplanktivorous silver carp (Hypoph
Relationships between microcystins and environmental parameters in 30 subtropical shallow lakes alon
Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis
Acute effects of microcystins on the transcription of 14 glutathione S-transferase isoforms in Wista
Plasma biochemical responses of the planktivorous filter-feeding silver carp (Hypophthalmichthys mol
Spatial and temporal variations of microcystins in hepatopancreas of a freshwater snail from Lake Ta
Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted
Distribution of toxins in various tissues of crucian carp intraperitoneally injected with hepatotoxi
Stable isotope changes in freshwater shrimps (Exopalaemon modestus and Macrobrachium nipponensis): T
Plasma biochemical responses of the omnivorous crucian carp (Carassius auratus) to crude cyanobacter
Experimental studies on the effects of toxic Microcystis aeruginosa PCC7820 on the survival and repr
In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and i
Accumulation of hepatotoxic microcystins in freshwater mussels, aquatic insect larvae and oligochaet
Field and laboratory studies on pathological and biochemical characterization of microcystin-induced
Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopa
Field and experimental studies on the combined impacts of cyanobacterial blooms and small algae on c
Simultaneous determination of microcystin-LR and its glutathione conjugate in fish tissues by liquid
相关项目
谢平的项目