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中文摘要：
完成了单臂单胺人工转氨酶作用机理的严格论证并在设计、合成双功能团人工模拟转氨酶方面做了较多的探索性工作。发现了首例以缩酮为烷化剂的Friedel-Crafts反应。深入研究了青蒿素类由单电子还原裂解机理，建立了完整的机理框架，为研究体内作用机制奠定了理论基础。创立了导向调控自由基裂解理论。发现了仿生条件下超微量铁引发的青蒿素裂解并率先提出了基于分子内烷化的作用机制的新学说。
结论摘要：
英文主题词Chiral total synthesis, natural products, methodology, asymmetric synthesis, mode of action
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期刊论文
Steroid-fullerene adducts from Diels-Alder reactions: characterization and the effect on the activit
Tandem Hemiketal Formation-Intramolecular Friedel-Crafts Alkylation. A Facile Route to the Hetero-At
Further Evidence for the Participation of Primary Carbon-Centered Free Radical in the Antimalarial A
How Might Qinghaosu (Artemisinin) and Related Compounds Kill the Intraerythrocytic Malaria Parasite?
A Formal Synthesis of ( )-Cassiol Exploiting Meyers’ Bicyclic Lactam Methodology to Construct the Qu
Synthesis of Natural Fragrant Molecules cis-3-Methyl-4-Decanolide and Aerangis Lactone. General Enan
Preferential Hydrolysis of Benzylic/Allylic Dithianes and Dithiolanes Using o-Iodoxybenzoic Acid (IB
Facile Cleavage of Triethylsilyl (TES) Ethers Using ortho-Iodoxybenzoic Acid (IBX) without Affecting
Synthesis of 3-Alkyl-5-Methyl-2(5H)- Furanone from Lactic Acid. Straightforward Synthesis of Two Pai
Remarkably accelerated regioselective hydrogenolysis of terminal epoxides in the presence of CoSO4 o
Probing the Possible Molecular Origin of the Highly Selective Toxicity of Antimalarial Peroxide Qing
Synthesis of a 5-oxo-2-tetrahydrofuranyl derivative of an Evans auxiliary via a novel reaction induc
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