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中文摘要：
本项目在微波技术、水溶剂、无溶剂或离子液体溶剂等绿色合成条件下开展了脱氧核苷、嘌呤核苷与嘧啶核苷的合成及各个位置官能团的修饰研究，尤其是在嘌呤核苷6位的磷修饰、氮修饰、碳修饰方面取得了创新性成果。将这些基础研究成果公开发表或应用于工业化生产，取得了优异的成绩共公开发表学术论文42篇，其中SCI源期刊论文23篇；在影响因子4以上本学科领域国际顶尖期刊发表8篇；在国内与国际学术会议上交流论文33篇；被邀请报告4篇；申请国家发明专利6项，授权3项；完成科技成果鉴定2项（均转化为工业生产，使企业新增产值年均超过5千万元）；获得国家科技进步二等奖1项；获得河南省自然科学优秀论文奖3项。由于本项目的实施，培养课题负责人获得 "国家级教学名师奖"、"全国三八红旗手"、"国务院特殊津贴"、" 全国第四届巾帼发明家创业奖"等多种荣誉称号，培养年轻课题组成员成为国家教育部新世纪学术带头人、成为河南省"555"人才。
结论摘要：
英文主题词deoxynucleosides,purine nucleosides , pyridine nucleosides ,green synthesis
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Microwave-promoted Michael addition in neat water: A rapid, efficient and green method for the prepa
Microwave-assisted rapid and regioselective synthesis of N-(alkoxycarbonylmethyl) nucleobases in wat
Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases - Buildi
Novel and Efficient Synthesis of Pyrazolo[3,4-b]pyridine-6-ones or Their Hydrogenated Derivatives th
Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic A
Ionic liquid promoted preparation of 4H-thiopyran and pyrimidine nucleoside-thiopyran hybrids throug
A novel one-step method for the synthesis of C-5-substituted O-6,5 '-cyclopyrimidine nucleoside anal
Microwave-promoted efficient synthesis of C6-cyclo secondary amine substituted purine analogues in n
A novel synthesis of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction in ionic l
A simple and efficient preparation of pyrazolo[3,4-b]-pyridine derivatives through an unexpected rea
Synthesis of novel C6-phosphonated purine nucleosides under microwave irradiation by SNAr-Arbuzov re
Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in
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