中文摘要：

目的：观察清胰承气汤内服结合双柏散结散外敷治疗重症急性胰腺炎（SAP）的临床疗效及对血清细胞因子的影响.方法：80例SAP随机按数字法分为对照组和观察组各40例,两组均参照“重症急性胰腺炎诊治指南”予禁食、胃肠减压、补充血容量、纠正水电解质酸碱失衡、使用生长抑素、奥美拉唑、抗生素治疗.观察组在对照组治疗的基础上加中药清胰承气汤内服及双柏散结散外敷.疗程均为7d.记录腹痛、腹胀缓解、肠鸣音恢复及通气排便时间,记录血象,血、尿淀粉酶恢复正常时间及平均住院时间、平均住院费用；检测治疗前后血清白介素-6（IL-6）、白介素-10（IL-10）、白介素-15（IL-15）及肿瘤坏死因子-α（TNF-α）水平.结果：观察组总有效率97.5％优于对照组的80％（P＜0.05）；观察组腹痛和腹胀缓解时间,肠鸣音恢复时间及首次排便时间均短于对照组（P＜0.01）；观察组平均住院时间及平均住院费用少于对照组（P＜0.01）；观察组血象、血、尿淀粉酶恢复正常时间均短于对照组（P＜0.01）；观察组血清IL-6、IL-15及TNF-α水平明显下降,并低于对照组（P＜0.01）,观察组血清IL-10明显上升且高于对照组（P＜0.01）.结论：清胰承气汤内服及双柏散结散外敷能明显改善急性期SAP腹痛、腹胀等肠麻痹症状,调节血清细胞炎性因子水平,减轻胰腺炎性的全身损伤,从而有利疾病的康复.

英文摘要：

Objective：Observed Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application treated severe acute pancreatitis （SAP） and effect of serum cytokines.Method：The 80 patients with SAP were randomly divided into control group and observation group.Each group had 40 patients.2 groups were reference to the ‘Severe Acute Pancreatitis Treat Guide’.Fasting,gastrointestinal decompression,Supplemented the blood volume,corrected water electrolyte acid-base balance,somatostatin,omeprazole,antibiotics treated.Observation group in on the basis of the control group with Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application treated.The treatment lasted 7 d.Recorded abdominal pain,abdominal bloating remission,recovery of bowel sounds and ventilation defecation time,recorded the hemogram,blood,urine amylase recovery time and average hospitalization time and average hospitalization costs.Before and after treatment we tested serum interleukin-6 （IL-6）,interleukin-10 （IL-10）,interleukin-15 （IL-15） and tumor necrosis factoralpha （TNF-α） levels.Result：The total effective rate of observation group was 97.5％ better than the 80％ of the control group （P ＜ 0.05）; the observation group abdominal pain and abdominal bloating remission time,the recovery of bowel sounds time and the time of first defecation time were shorter than the control group （P ＜ 0.01） ;observation group,average hospitalization time and average hospitalization costs was less than that of the control group （P ＜0.01） ; the observation group normal hemogram time,blood,urine amylase recovery time were shorter than the control group （P ＜ 0.01） ; observation group serum IL-6,IL-15 and TNF-α level decreased significantly,and lower than the control group （P ＜ 0.01）,the observed serum IL-10 significantly increased and higher than control group （P ＜ 0.01）.Conclusion：Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application could be significantly i