中文摘要：

指向的药能显著地减少细胞毒素的效果并且增加治疗学的活动。Dihydroartemisinin (DHA ) 被显示了在杀死癌症房间有效。然而，它展出非指向的性质。Holo-transferrin (TF ) 是一个合适的药搬运人指向癌症房间，因为癌症房间需要由维持他们的不受管束的生长的调停 TF 的机制熨举起。而且， TF 受体(TF-R ) 高度在癌症房间表面上被表示。在这份报纸，3-( 4,5-dimethylthi-azol-2-yl ) -2,5-diphenyltetrazolium 溴化物( MTT )试金被用来评估4-( 12-Dihydroart-emisininoxy )的不同杀死效果人的乳癌房间( MCF-7 )上的安息香的酸 Hydrozide-transferrin ( DBAH-TF )房间和人的正常的胸( HNB )房间，并且原子力量显微镜学( AFM )被用来视觉上在 MCF-7 房间上观察 DBAH-TF 的指向的效果。MTT 结果证明 DBAH-TF 比在杀死 MCF-7 房间的 DHA 是乘更多的有势力的 172，当 HNB 房间上的 DBAH-TF 的细胞毒素的效果仅仅是到 DHA 的 1/33 时。另外， MCF-7 房间上的 DBAH-TF 的杀死的效果在 HNB 房间上是乘那的 286，显示出指向的效果。而且，在在 DBAH-TF 和 DHA 治疗以后的细胞的表面的超微结构有不同差别。通过 AFM 成像，许多典型的洞在被 DBAH-TF 完成以后在癌症房间表面上被观察，它不同于洞，不规则的形状由 DHA 影响了。这些结果视觉上证明指向的药更有有势力杀死的 DBAH-TF 与 DHA 相比在 MCF-7 上完成房间。

英文摘要：

Targeted drugs could significantly reduce cytotoxic effect and increase therapeutic activity. Dihydroartemisinin （DHA） has been shown to be effective in killing cancer cells. However, it exhibits non-targeted property. Holo-transferrin （TF） is a suitable drug-carrier to target cancer cells, because cancer cells need iron uptake by the TF-mediated mechanism to maintain their uncontrolled growth. Furthermore, TF receptors （TF-R） are highly expressed on cancer cell surfaces. In this paper, 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay was used to evaluate the different killing effect of 4-（12-Dihydroartemisininoxy） Benzoic Acid Hydrozide-transferrin （DBAH-TF） on human breast cancer cells （MCF-7） ceils and human normal breast （HNB） cells, and atomic force microscopy （AFM） was used to visually observe the targeted effect of DBAH-TF on MCF-7 cells. MTT results show that DBAH-TF is 172 times more potent than DHA in killing MCF-7 cells, while the cytotoxic effect of DBAH-TF on HNB cells is merely 1/33 to DHA. Also, the killing effect of DBAH-TF on MCF-7 cells is 286 times that on HNB cells, showing targeted effect. Moreover, there are distinct differences in ultrastructures of cellular surfaces after DBAH-TF and DHA treatment. Through AFM imaging, many characteristic holes were observed on the cancer cell surface after being effected by DBAH-TF, which differ from the holes with irregular shapes affected by DHA. These results visually show that the DBAH-TF targeted drug has more potent killing effect on MCF-7 cells compared with DHA.